曲美他嗪辅助利巴韦林对柯萨奇病毒感染致心肌炎伴心力衰竭患者对心肌酶的影响  

Influence on Myocardial Enzymes of Trimetazidine Assisted Ribavirin in Heart Failure Patients with Myocarditis Infected by Coxsackie Virus

作　　者：张磊 ZHANG Lei(Huiji District People's Hospital of Zhengzhou,Zhengzhou 450000,China)

机构地区：[1]郑州市惠济区人民医院,郑州450000

出　　处：《抗感染药学》2020年第3期400-402,共3页Anti-infection Pharmacy

摘　　要：目的:探究曲美他嗪辅助利巴韦林对柯萨奇病毒感染致心肌炎伴心力衰竭患者的疗效及其对心肌酶指标改善的影响。方法:选取2017年3月-2019年3月间收治的柯萨奇病毒性感染致心肌炎伴心力衰竭患者124例资料,将其按照治疗方案的不同分为利巴韦林组和联用组,每组62例;利巴韦林组患者给予利巴韦林与常规药物治疗,联用组患者在利巴韦林组基础上加用曲美他嗪治疗,比较两组患者治疗前后的心肌酶各指标,如肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)及乳酸脱氢酶(LDH)等测得值的变化情况,以及治疗期间不良反应发生率的差异。结果:两组患者不同药物治疗后心肌酶各指标(CK、CK-MB及LDH)测得值较治疗前均有明显改善,且联用组改善程度优于利巴韦林组(P<0.05);联用组患者用药期间不良反应发生率略高于利巴韦林组(17.14%vs9.67%),但经组间比较其差异无统计学意义(P>0.05)。结论:基于柯萨奇病毒感染致心肌炎并发心力衰竭患者,采用曲美他嗪辅助利巴韦林治疗,有效改善了其心肌酶指标,改善了心功能。Objective: To investigate the efficacy of trimetazidine assisted ribavirin in heart failure patients with myocarditis infected by Coxsackie virus and its influence on the improvement of myocardial enzyme indexes. Methods:Data of 124 patients with myocarditis caused by Coxsackie viral infection with heart failure admitted from March 2017 to March 2019 were selected. They were divided into ribavirin group and combination group according to different treatment regimens, with 62 patients in each group. Patients in the ribavirin group were treated with ribavirin and conventional drugs, while patients in the combination group were treated with trimetazidine on the basis of ribavirin group. The changes of myocardial enzyme indexes(CK, CK-MB and LDH) before and after treatment and the differences in the incidence of adverse drug reactions during treatment were compared between the two groups. Results: The indexes of myocardial enzymes(CK, CK-MB and LDH) in the two groups were significantly improved after treatment with different drugs, and the improvement in the combined group was better than that in the ribavirin group(P<0.05). The incidence of adverse drug reactions in the combination group was slightly higher than that in the ribavirin group(17.14% vs9.67%), but the difference was not statistically significant(P>0.05). Conclusion: Based on heart failure patients with myocarditis infected by Coxsackie virus, trimetazidine assisted ribavirin treatment effectively improved its myocardial enzyme index and cardiac function.

关 键 词：曲美他嗪 利巴韦林 柯萨奇病毒 心肌炎 心力衰竭 心肌酶指标 

分 类 号：R969.4[医药卫生—药理学]