舒脑欣滴丸对寒凝气滞血瘀证大鼠血小板聚集和血液流变学指标的影响  

Effects of Shunaoxin Drop Pills on platelet aggregation and hemorheology in rats with cold qistagnation of blood stasis syndrome

作　　者：张蕊[1] 郝春华[1] 孙双勇[1] 徐向伟[1] 席文恭 赵专友[1] 王维亭[1] 汤立达[1] ZHANG Rui;HAO Chun-hua;SUN Shuan-yong;XU Xiang-wei;XI Wen-gong;ZHAO Zhuan-you;WANG Wei-ting;TANG Li-da(Tianjin Institute of Pharmaceutical Research New Drug Safety Evaluation Co.Ltd,Tianjin 300301,China)

机构地区：[1]天津药物研究院新药评价有限公司,天津300301

出　　处：《现代药物与临床》2020年第2期206-211,共6页Drugs & Clinic

基　　金：天津市第二批特支计划青年拔尖人才基金资助项目(TJTZJHQNBJRC-2-7)。

摘　　要：目的探讨舒脑欣滴丸对急性血瘀模型大鼠血小板聚集和血液流变学指标的影响。方法选取70只Wistar大鼠,随机分为对照组,模型组,舒脑欣滴丸13、26、52 mg/kg组,阳性药脑心通胶囊(15 mg/kg)、阿司匹林肠溶片(15 mg/kg)和藻酸双脂钠片(90 mg/kg)组,连续ig给药7 d,1次/d,末次给药后1 h,采用sc 0.1%肾上腺素加在冰水中游泳的方法,制备大鼠急性血瘀模型,观察舒脑欣滴丸对不同血小板聚集诱导剂二磷酸腺苷(ADP)、花生四烯酸(AA)和胶原(CG)引起的大鼠血小板聚集影响;通过检测血液流变学指标、凝血功能评价舒脑欣滴丸对血瘀模型大鼠的作用。结果舒脑欣滴丸对3种不同血小板聚集诱导剂引起的血小板聚集均有不同程度的抑制作用,可显著降低全血黏度,延长血瘀模型大鼠凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)。结论舒脑欣滴丸13、26、52 mg/kg具有明显活血化瘀作用,能降低血液黏度,抑制多种诱导剂引起的血小板聚集,具有一定抗凝活性。Objective To investigate the effect of Shunaoxin Dropping Pills on platelet aggregation and hemorheology in rats with acute blood stasis. Methods Wistar rats(70 cases) were randomly divided into control group, model group, Shunaoxin Dropping Pills(13, 26 and 52 mg/kg) groups, positive drugs Naoxintong Capsules(15 mg/kg), Aspirin Enteric-coated Tablets(15 mg/kg), and Alginic Sodium Diester Tablets(90 mg/kg) groups. Rats were administrated continuously for 7 d, once daily. One hour after the last administration, the rats were injected sc with 0.1% adrenaline and swimming in ice water to prepare acute blood stasis model. The effects of Shunaoxin Dropping Pills on platelet aggregation induced by adenosine diphosphate(ADP), arachidonic acid(AA), and collagen(CG) were observed. The effects of Shunaoxin Dropping Pills on blood stasis model rats were evaluated by detecting hemorheology indexes and coagulation function. Results Shunaoxin Dropping Pills had different inhibitory effects on platelet aggregation induced by three kinds of platelet aggregation inducers. Shunaoxin Dropping Pills could reduce blood viscosity, and prolong prothrombin time(PT) and activated partial thromboplastin time(APTT) of rats with blood stasis. Conclusion Shunaoxin Dropping Pills(13, 26, and 52 mg/kg) can obviously promote blood circulation, remove blood stasis, reduce blood viscosity, and inhibit platelet aggregation caused by various inducers, and have certain anticoagulant activity.

关 键 词：舒脑欣滴丸 血瘀模型 血小板聚集 凝血功能 血液流变学 

分 类 号：R285.5[医药卫生—中药学]