百令胶囊对桥本甲状腺炎自身免疫性抗体影响的Meta分析  

Efficacy of Bailing capsule for autoimmune antibodies in Hashimoto thyroiditis:a meta-analysis

作　　者：柳杨青 汪艳芳[2] 郭丽君 LIU Yangqing;WANG Yanfang;GUO Lijun(Henan University People's Hospital,Zhengzhou 450003,P.R.China;Department of Endocrinology,Henan Provincial People’s Hospital,Zhengzhou 450003,P.R.China;Jinzhou Medical University,Jinzhou 121000,P.R.China)

机构地区：[1]河南大学人民医院,郑州450003 [2]河南省人民医院内分泌科,郑州450003 [3]锦州医科大学,辽宁锦州121000

出　　处：《中国循证医学杂志》2020年第4期453-457,共5页Chinese Journal of Evidence-based Medicine

基　　金：河南省医学科技攻关计划省部共建项目(编号:SBGJ2018069)。

摘　　要：目的系统评价百令胶囊对桥本甲状腺炎(HT)自身免疫性抗体的影响。方法计算机检索PubMed、EMbase、The Cochrane Library、CBM、WanFang Data和CNKI数据库,搜集百令胶囊治疗桥本甲状腺炎的随机对照试验(RCT),检索时限均为建库至2019年1月。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果共纳入7个RCT,包括428例患者。Meta分析结果显示:百令胶囊+优甲乐组在抗甲状腺球蛋白抗体(TGAb)、抗甲状腺过氧化物酶抗体(TPOAb)水平的改善程度优于对照组[MD=-228.91,95%CI(-398.61,-59.20),P=0.008;MD=-158.19,95%CI(-222.44,-93.94),P<0.00001];百令胶囊+低碘饮食组TGAb、TPOAb的改善程度优于对照组[MD=-499.27,95%CI(-540.39,-458.15),P<0.00001;MD=-407.37,95%CI(-448.60,-366.14),P<0.00001]。结论当前证据表明,百令胶囊与其他治疗联用可能会降低HT患者TGAb、TPOAb水平。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。Objectives To systematically review the efficacy of Bailing capsule for autoimmune antibodies in Hashimoto thyroiditis(HT).Methods PubMed,EMbase,The Cochrane Library,CBM,WanFang Data and CNKI databases were electronically searched to collect the randomized controlled trials(RCTs)on Bailing capsule in treatment of HT from inception to January 2019.Two reviewers independently screened literature,extracted data and assessed the risk of bias of included studies,then,meta-analysis was performed by using RevMan 5.3 software.Results A total of 7 RCTs involving 428 patients were included.The results of meta-analysis showed that the changes of TGAb and TPOAb in Bailing capsule combined with Euthyrox group were higher than that in control group(MD=-228.91,95%CI-398.61 to-59.20,P=0.008;MD=-158.19,95%CI-222.44 to-93.94,P<0.00001);the changes of TGAb and TPOAb in Bailing capsule combined with Iodine modification diet group were higher than that in control group(MD=-499.27,95%CI-540.39 to-458.15,P<0.00001;MD=-407.37,95%CI-448.60 to-366.14,P<0.00001).Conclusions Current evidence shows that Bailing capsule combined with other therapies can decrease the levels of TGAb and TPOAb in HT patients.Due to limited quality and quantity of the included studies,more high-quality studies are required to verify the above conclusion.

关 键 词：百令胶囊 桥本甲状腺炎 自身免疫性抗体 META分析 系统评价 随机对照试验 

分 类 号：R581.4[医药卫生—内分泌]