血浆ET-1水平与老年2型糖尿病下肢血管病变程度的相关性研究  

Correlation between Plasma ET-1 Level and the Degree of Lower Extremity Vascular Disease in Elderly Type 2 Diabetic Patients

作　　者：寿璋 赵永才[1] 张燕[1] 李少情 SHOU Zhang;ZHAO Yongcai;ZHANG Yan(Cangzhou Central Hospital, Hebei Cangzhou 061000, China)

机构地区：[1]河北省沧州市中心医院内分泌糖尿病四科,河北沧州061000

出　　处：《河北医学》2020年第4期657-660,共4页Hebei Medicine

基　　金：河北省沧州市重点研发计划指导项目,(编号:183302057)。

摘　　要：目的:探讨血浆内皮素-1(endothelin-1,ET-1)水平与老年2型糖尿病下肢血管病变程度的相关性。方法:随机选取我院2015年1月至2019年1月收治的老年糖尿病合并下肢血管病变患者136例,依据老年患者踝肱指数(ABI)测定结果将纳入患者分为轻度下肢动脉硬化组84例(0.7≤ABI<0.9),中度下肢动脉硬化组36例(0.5≤ABI<0.7),重度下肢动脉硬化组16例(ABI<0.5),葡萄糖氧化酶法测定空腹血糖(FBG),色谱法测定糖化血红蛋白(HbA1c),全自动生化分析仪测定胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、三酰甘油(TG)等,酶联吸附法测定血浆ET-1,对比三组不同下肢动脉硬化组患者血浆ET-1水平,并分析不同肢大动脉病变程度与血浆ET-1的相关性。结果:2型糖尿病下肢动脉不同病变程度组间的年龄、BMI、TC、TG、LDL、HDL、患者病程、空腹血糖及ET-1对比具有差异性(P<0.05);经多因素Logistic回归分析表明,空腹血糖、糖尿病病程及ET-1均为影响下肢动脉病变程度的独立危险因素。经Spearman等级相关性分析可知糖尿病下肢血管病变程度与ET-1呈正相关关系(r=0.336,P=0.000)。结论:2型糖尿病下肢血管病变程度独立危险因素为空腹血糖、糖尿病病程及ET-1,与ET-1呈正相关关系。Objective:To investigate the correlation between plasma endothelin-1(ET-1)level and the degree of lower extremity vascular disease in elderly patients with type 2 diabetes.Methods:A total of 136 elderly patients with diabetes mellitus and lower extremity vascular disease treated in our hospital from January 2015 to January 2019 were randomly selected.Based on the results of ankle brachial index(ABI)measurement in elderly patients,they were divided into a 84 patients mild lower extremity arteriosclerosis group(0.7≤ABI<0.9),a 36 patients moderate lower extremity arteriosclerosis group(0.5≤ABI<0.7),and a 16 patients severe lower extremity arteriosclerosis group(ABI<0.5),Glucose oxidase method was used to measure fasting blood glucose(FBG),chromatographic method was used to measure glycated hemoglobin(HbA1c),and automatic biochemical analyzer was used to measure the cholesterol(TC),high density lipoprotein(HDL),low density lipoprotein(LDL),and triacylglycerol(TG),etc.The enzyme-linked adsorption method was used to measure the plasma ET-1 levels in patients among different lower extremity arteriosclerosis groups,and we analyzed the correlation between the degree of aortic lesions in different limbs and the level of plasma ET-1.Results:There were significant differences in age,BMI,TC,TG,LDL,HDL,course of disease,blood glucose under fasting,and ET-1 level between groups with different degrees of pathological changes of lower extremity arteries in type 2 diabetes(P<0.05).Logistic regression analysis showed that,fasting blood glucose,duration of diabetes,and ET-1 are independent risk factors that affect the degree of arterial disease in the lower limbs.Spearman rank correlation analysis showed that the degree of diabetic lower extremity vascular lesions was positively correlated with ET-1(r=0.336,P=0.000).Conclusion:The independent risk factors for the degree of lower extremity vascular disease in type 2 diabetes are fasting blood glucose,duration of diabetes,which are positively correlated with ET-1 level.

关 键 词：内皮素-1 2型糖尿病 下肢血管病变 相关性 

分 类 号：R587.2[医药卫生—内分泌]