血管生成素样因子与动脉硬化性疾病的相关性研究进展  

Research advances on the association between angiopoietin-like proteins and arteriosclerotic diseases

作　　者：冷昶木 盖晴 丛树艳[1] LENG Changmu;GAI Qing;CONG Shuyan(Department of Neurology,Shengjing Hospital,China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院神经内科,沈阳110004

出　　处：《中国医科大学学报》2020年第4期362-368,共7页Journal of China Medical University

基　　金：国家自然科学基金(81371271)。

摘　　要：血管生成素样因子(ANGPTLs)是近年来发现的一类与血管生成素(ANG)在组成上具有同源性,并具有调节血管生成作用的分泌性糖蛋白家族。目前已发现ANGPTLs家族有8个成员(ANGPTL1~8),ANGPTL2、3、4主要通过调整糖脂代谢、影响血管生成等影响动脉硬化产生,本文就ANGPTLs蛋白家族各个成员特点、功能、致病机制及其与动脉硬化性疾病相关性的研究进展进行综述。Angiopoietin-like proteins(ANGPTLs),a family of secretory glycoproteins,were found to be constitutionally homologous with angiogenin,and play a role in the regulation of angiogenesis.There are eight members of the ANGPTLs family,which are known as ANGPTL1-8.ANGPTL2,ANGPTL3,and ANGPTL4 affect arteriosclerosis primarily by adjusting glucose and lipid metabolism,and by regulating angiogenesis.This study summarizes the characteristics,functions,and pathogenesis of each member of the ANGPTLs protein family.Additionally,advances in their relationship with arteriosclerotic disease were also reviewed.

关 键 词：血管生成素样因子 糖脂代谢 血管损伤 动脉硬化 

分 类 号：R543.5[医药卫生—心血管疾病]