生长分化因子15与血管疾病研究进展  

Progress Research of Growth Differentiation Factor-15 in Vascular Diseases

作　　者：宋佳玮 刘颖 王娟 钟久昌 SONG Jia-wei;LIU Ying;WANG Juan;ZHONG Jiu-chang(Heart Center and Beijing Key Laboratory of Hypertension,Beijing Chao-Yang Hospital,Capital Medical University,Beijing 100020,China)

机构地区：[1]首都医科大学附属北京朝阳医院心脏中心北京市高血压重点实验室,北京市100020

出　　处：《中国分子心脏病学杂志》2020年第1期3264-3267,共4页Molecular Cardiology of China

基　　金：国家自然科学基金项目(81770253,81370362,81900382);国家重大研究计划资助项目(91339108)。

摘　　要：生长分化因子15(GDF-15)隶属于转化生长因子-β超家族,主要参与细胞增殖、血管重构及血管生成调节,发挥抗炎症、抗凋亡、抗纤维化功效。GDF-15与高血压等血管疾病的严重程度有关,其表达异常参与高血压、动脉粥样硬化、急性冠脉综合征、肺动脉高压等血管疾病的发病。本文主要介绍GDF-15的结构特征、生物学效应及其在血管疾病的预后评估及临床指导价值新进展。Growth differentiation factor-15(GDF-15),a member of the transforming growth factor-βcytokine superfamily,participates in cell proliferation,vascular remodeling and angiogenesis regulation and has anti-inflammatory,anti-apoptotic and anti-fibrotic properties.GDF-15 is related to the severity of vascular diseases such as hypertension,and its abnormal expression is involved in the pathogenesis of vascular diseases including hypertension,atherosclerosis,acute coronary syndrome and pulmonary hypertension.In this paper,we will give a brief introduction of the structural characteristics and biological effects of GDF-15 and its new progress in the prognosis evaluation and clinical treatment guidance value of vascular diseases.

关 键 词：生长分化因子15 动脉粥样硬化 急性冠脉综合征 高血压 肺动脉高压 

分 类 号：R54[医药卫生—心血管疾病]