间充质干细胞来源的脱细胞基质及其研究进展  

Mesenchymal stem cell derived extracellular matrix and its research progress

作　　者：冯煜婷 姜治伟 杨国利[1,2] 谢志坚 FENG Yuting;JIANG Zhiwei;YANG Guoli;XIE Zhijian(Department of Implantology,Stomatology Hospital,School of Medical,Zhe-jiang University,Hangzhou 310006,China)

机构地区：[1]浙江大学医学院附属口腔医院种植科,浙江杭州310006 [2]浙江省口腔生物医学研究重点实验室,浙江杭州310006 [3]浙江大学医学院附属口腔医院颌面外科,浙江杭州310006

出　　处：《口腔医学》2020年第3期271-274,280,共5页Stomatology

基　　金：国家自然科学基金(81901051);浙江省卫生厅科技项目(2018KY499)。

摘　　要：干细胞一直是国内外医学研究的热点,尤其在再生医学领域。间充质干细胞作为应用较广泛的干细胞,通过近年来的研究,其分泌的细胞外基质已经可以被有效获取,它对细胞的增殖、生长以及定向分化有相应的促进作用,具有供体来源丰富、可防止病原传染、减少自身免疫反应等优势,是组织工程学研究的理想生物材料。本文就间充质干细胞来源的脱细胞基质的概念、成分、获取方法、研究进展及应用前景作一综述。Stem cells have been a hotspot of medical research at home and abroad,especially in the field of regenerative medicine.As one of the most widely used stem cells,mesenchymal stem cell derived extracellular matrix(MSC-ECM)has been successfully isolated and proved to be effective in cell proliferation,development and orientated differentiation and so on through recent research.Furthermore,because of its rich resources,preventing pathogen transmission and reducing autoimmunity,MSC-ECM is considered to be an ideal biological material for tissue engineering.This comprehensive review mainly focused on concept,ingredient,the acquisition methods,research progress and application prospect of mesenchymal stem cell-derived extracellular matrix.

关 键 词：间充质干细胞 细胞外基质 组织工程 骨再生 

分 类 号：R329.28[医药卫生—人体解剖和组织胚胎学]