重组人表皮生长因子凝胶联合中药治疗面部糖皮质激素依赖性皮炎疗效分析  

Effi cacy of Recombinant Human Epidermal Growth Factor Gel Combined with Traditional Chinese Medicine on Facial Corticosteroid Addictive Dermatitis

作　　者：尹诗 张静 罗丽娜 韩俊 YIN Shi;ZHANG Jing;LUO Li-na;HAN Jun(Department of Dermatology,Guang'an People's Hospital(West China Guang'an Hospital,Sichuan University),Guang'an 638000,Sichuan,China])

机构地区：[1]广安市人民医院(四川大学华西广安医院)中医科,四川广安638000 [2]广安市人民医院(四川大学华西广安医院)皮肤科,四川广安638000

出　　处：《中国美容医学》2020年第2期95-98,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探讨重组人表皮生长因子凝胶联合中药治疗面部糖皮质激素依赖性皮炎(FCAD)的疗效。方法:收集124例FCAD(热毒蕴结型)患者资料,随机分为对照组和观察组,两组均给予口服复方甘草酸苷片,对照组加用重组人表皮生长因子凝胶外敷治疗,观察组在对照组用药基础上加服中药(清热解毒方)治疗。观察两组治疗前及治疗4周后的中医症状积分,评估两组临床疗效,对比两组治疗前及治疗4周的皮肤功能指标和T淋巴亚群细胞水平。结果:治疗4周后,两组患者的红斑、丘疹、干燥脱屑及痛痒灼热四项中医症状评分均显著降低(P<0.05),观察组下降幅度显著大于对照组(P<0.05);观察组临床总有效率可达88.71%,显著高于对照组的72.58%(P<0.05);治疗4周后,两组患者的表皮油脂含水量、表皮含水量显著提高(P<0.05),经皮水分丢失(TEWL)值显著降低,两组患者的外周血CD4+、CD8+T淋巴细胞亚群含量和CD4+/CD8+T淋巴细胞亚群比值显著降低(P<0.05),观察组变化幅度显著大于对照组(P<0.05)。结论:重组人表皮生长因子凝胶联合中药治疗FCAD疗效确切,能明显减轻其红斑、丘疹、干燥脱屑及痛痒灼热等症状,有效促进皮损及早修复和皮肤屏障功能提高。Objective To investigate the effi cacy of recombinant human epidermal growth factor gel combined with traditional Chinese medicine in the treatment of facial corticosteroid addictive dermatitis(FCAD).Methods The data of 124 cases of FCAD patients(heat-toxic accumulating type of drug toxicity)were collected,and the patients were randomly divided into control group and observation group.They were given compound glycyrrhizin tablets,and control group was treated with external application of recombinant human epidermal growth factor gel,and observation group was additionally given traditional Chinese medicine(Qingre Jiedu prescription)on the basis of control group.The TCM symptoms scores were observed in the two groups before treatment and after 4 weeks of treatment.The clinical efficacy in the two groups was evaluated.The skin function indexes and T lymphocyte subsets were compared between the two groups before treatment and after 4 weeks of treatment.Results After 4 weeks of treatment,the scores of four items of TCM symptoms of erythema,papules,dry desquamation and itching and burning were signifi cantly decreased in the two groups(P<0.05),and the decreases in observation group were signifi cantly greater than those in control group(P<0.05).The total clinical effective rate was up to 88.71%in observation group,which was signifi cantly higher than 72.58%in control group(P<0.05).After 4 weeks of treatment,the epidermal grease water content and epidermal water content were significantly increased in the two groups(P<0.05),and the transepidermal water loss(TEWL)value was signifi cantly decreased,and the CD4+and CD8+T lymphocyte subsets and ratio of CD4+/CD8+T lymphocyte subsets in peripheral blood in the two groups were signifi cantly decreased(P<0.05),and the changes in observation group were signifi cantly greater than those in control group(P<0.05).Conclusion Recombinant human epidermal growth factor gel combined with traditional Chinese medicine has exact effi cacy in the treatment of FCAD,and it can signifi cantly

关 键 词：面部糖皮质激素依赖性皮炎 重组人表皮生长因子凝胶 中药 皮肤功能指标 T淋巴亚群细胞水平 

分 类 号：R758.22[医药卫生—皮肤病学与性病学]