2014~2017年承德市女性HPV亚型感染情况及分布特点  

Infection Status and Distribution Characteristics of Female HPV Subtypes in Chengde City from 2014 to 2017

作　　者：秦燕 王杏茶[1] 方淑琴[1] 郝云涛[1] QIN Yan;WANG Xing-cha;FANG Shu-qin;HAO Yun-tao(Department of Gynecology,Subject One,the Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei,China)

机构地区：[1]承德医学院附属医院妇一科,河北承德067000

出　　处：《医学信息》2020年第8期144-146,共3页Journal of Medical Information

摘　　要：目的了解承德市女性HPV亚型感染情况及在各年龄段的分布特点,为预防HPV感染和宫颈癌防治提供参考。方法选取2014~2017年就诊于承德医学院附属医院的16338例门诊及住院患者,采取医用核酸分子杂交系统流式荧光杂交法进行27种HPV基因亚型检测。结果16338例样本中,阳性4392例,阳性率26.89%,27种基因亚型全部被检出,其中高危型2325例,低危型648例,混合感染型1419例。高危型HPV感染率最高的为HPV16型,其次为HPV58、52、18、53型;低危型HPV感染率最高的为HPV61型,其次为HPV6、43、81、42型,总检出率最高的为HPV16型,其次为HPV58、52、61、18型。各年龄段HPV感染分布呈双峰型,≤25岁及56~65岁HPV感染率出现高峰。结论HPV感染存在地域差异,了解承德市女性HPV亚型感染情况及各年龄段的分布特点,加强对承德市各年龄段女性多种型别HPV的监测及筛查,可为承德市女性宫颈癌的防治提供流行病学数据,指导临床治疗。Objective To understand the HPV subtype infection of women in Chengde City and their distribution characteristics at various ages,so as to provide a reference for the prevention of HPV infection and cervical cancer prevention.Methods A total of 16338 outpatients and in-patients who were admitted to the Affiliated Hospital of Chengde Medical College from 2014 to 2017 were selected,and 27 types of HPV genotypes were detected by flow fluorophore hybridization using medical nucleic acid molecular hybridization system.Results Among the 16338 samples,4392 were positive,with a positive rate of 26.89%.All 27 gene subtypes were detected,including 2325 high-risk types,648 low-risk types,and 1419 mixed infection types.High-risk HPV infection rate is the highest type HPV16,followed by HPV58,52,18,53;low-risk HPV infection rate is the highest type HPV61,followed by HPV6,43,81,42 type,the highest total detection rate type is HPV16,followed by HPV58,52,61,18 type.The distribution of HPV infection in each age group is bimodal,with peaks in HPV infection rates of≤25 years old and 56-65 years old.Conclusion There are regional differences in HPV infection,understand the HPV subtype infection status and the distribution characteristics of various age groups of women in Chengde City,strengthen the monitoring and screening of multiple types of HPV of women of all age groups in Chengde City,with a view to the cervical cancer of women in Chengde City Prevention and treatment provides epidemiological data to guide clinical treatment.

关 键 词：人乳头瘤病毒 宫颈癌 基因型 亚型分布 

分 类 号：R445.1[医药卫生—影像医学与核医学]