A Review on Surface?Functionalized Cellulosic Nanostructures as Biocompatible Antibacterial Materials  

作　　者：Mandana Tavakolian Seid Mahdi Jafari Theo GMvan de Ven 

机构地区：[1]Department of Chemical Engineering,McGill University,Montreal,QC H3A 0C5,Canada [2]Pulp and Paper Research Center,McGill University,Montreal,QC H3A 0C7,Canada [3]Quebec Centre for Advanced Materials(QCAM/CQMF),Montreal,Canada [4]Department of Food Materials and Process Design Engineering,Gorgan University of Agricultural Science and Natural Resources,Gorgan,Iran [5]Department of Chemistry,McGill University,Montreal,QC H3A 0B8,Canada

出　　处：《Nano-Micro Letters》2020年第6期90-112,共23页纳微快报（英文版）

基　　金：the Natural Sciences and Engineering Research Council of Canada(NSERC);an NSERC-FPinnovations CRD grant for supporting this research;McGill University for a MEDA fellowship.

摘　　要：As the most abundant biopolymer on the earth,cellulose has recently gained significant attention in the development of antibacterial biomaterials.Biodegradability,renewability,strong mechanical properties,tunable aspect ratio,and low density offer tremendous possibilities for the use of cellulose in various fields.Owing to the high number of reactive groups(i.e.,hydroxyl groups)on the cellulose surface,it can be readily functionalized with various functional groups,such as aldehydes,carboxylic acids,and amines,leading to diverse properties.In addition,the ease of surface modification of cellulose expands the range of compounds which can be grafted onto its structure,such as proteins,polymers,metal nanoparticles,and antibiotics.There are many studies in which cellulose nano-/microfibrils and nanocrystals are used as a support for antibacterial agents.However,little is known about the relationship between cellulose chemical surface modification and its antibacterial activity or biocompatibility.In this study,we have summarized various techniques for surface modifications of cellulose nanostructures and its derivatives along with their antibacterial and biocompatibility behavior to develop non-leaching and durable antibacterial materials.Despite the high effectiveness of surface-modified cellulosic antibacterial materials,more studies on their mechanism of action,the relationship between their properties and their effectivity,and more in vivo studies are required.

关 键 词：Cellulose NANOCELLULOSE SURFACE modification Antibacterial activity BIOCOMPATIBILITY 

分 类 号：TB34[一般工业技术—材料科学与工程]