冠状病毒疫苗研究进展及2019新型冠状病毒疫苗研发展望  

Research and development of coronavirus vaccine and prospect of 2019 novel coronavirus vaccines

作　　者：张明顺 吉宁飞[3] ZHANG Mingshun;JI Ningfei(Department of Immunology,National Health Commission,Nanjing Medical University,Nanjing 211166;Key Laboratory of Antibody Techniques,National Health Commission,Nanjing Medical University,Nanjing 211166;Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学基础医学院免疫学系,江苏南京211166 [2]南京医科大学国家卫生健康委员会抗体技术重点实验室,江苏南京211166 [3]南京医科大学第一附属医院呼吸与危重症医学科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2020年第2期151-154,159,共5页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金面上项目(81671563)。

摘　　要：2019新型冠状病毒传染性强,危重症发生率高,亟需有效的防控手段。疫苗接种是保护易感者,阻断传染性疾病传播的重要措施。文章总结了2002年SARS冠状病毒和2012年MERS冠状病毒疫苗灭活疫苗、亚单位疫苗和DNA疫苗研究进展。结合冠状病毒疫苗研究进展、牛痘苗的历史经验以及2019新型冠状病毒的特点,展望了2019新型冠状病毒疫苗研发的可能途径。The emergence and outbreak of 2019 novel coronavirus(2019-nCoV)have posed a great challenge. Vaccination is an effective way to protect the susceptible from the spread of infectious diseases. The purpose of this essay is to review the inactivated vaccine,subunit vaccine and DNA vaccine research progress of 2002 severe acute respiratory syndrome(SARS)coronavirus and 2012 middle east respiratory syndrome(MERS)coronavirus. Combined with the coronavirus vaccine progress,the history of vaccinia vaccine,and the characteristics of coronaviruses,we provide some potential approachesof vaccine development for 2019-nCoV.

关 键 词：2019新型冠状病毒 灭活疫苗 亚单位疫苗 DNA疫苗 

分 类 号：R563.14[医药卫生—呼吸系统]