易感基因HLA-B*35及其亚型在中国大陆的分布  

Distribution of HLA-B*35 high resulaton type in subacute thyroiditis in China's Mainland

作　　者：樊甦 马骁 潘芹芹 王晓艳 张志欣[2] 蔡剑平 毛伟[4] 王振雷[5] 陈强 李剑平 张德梅 刘琪 吴宝红 沈捷 FAN Su;MA Xiao;PAN Qinqin;WANG Xiaoyan;ZHANG Zhixin;CAI Jianping;MAO Wei;WANG Zhenlei;CHEN Qiang;LI Jianping;ZHANG Demei;LIU Qi;WU Baohong;SHEN Jie(The Center of HLA and Transplant Immonology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029;Beijing Red Cross Blood Center,Beijing 100088;Quality Control Laboratory,China Bone Marrow Program,Beijing 100730;Chongqing Blood Center,Chongqi 400015;Hebei Blood Center,Shijiazhuang 050061;Institute of Blood Transfusion,Chinese Academy of Medical Sciences&Peking Union Medical College,Chengdu 610052;Liaoning Blood Center,Shenyang 110096;Taiyuan Red Cross Blood Center,Taiyuan 030024;Department of HLA Technology,China Bone Marrow Program,Beijing 100010;Department of Endocrinology and Metabolism,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院HLA与移植免疫实验中心,江苏南京210029 [2]北京市红十字血液中心,北京100088 [3]中华骨髓库质量控制实验室,北京100703 [4]重庆市血液中心,重庆400015 [5]河北省血液中心,河北石家庄050061 [6]中国医学科学院输血研究所,四川成都610052 [7]辽宁省血液中心,辽宁沈阳110096 [8]太原市红十字中心血站,山西太原030024 [9]中国造血干细胞捐献者资料库管理中心技术服务部,北京100010 [10]南京医科大学第一附属医院内分泌科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2020年第2期210-216,共7页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省卫生厅面上项目(Z201401)。

摘　　要：目的:明确易感基因HLA-B*35及其亚型在中国大陆人群总体及区域分布情况,以期为相关疾病,尤其是亚急性甲状腺炎的诊断和鉴别诊断提供参考。方法:中国大陆941 902例健康成人经HLA基因高分辨分型并按31个省市、自治区、直辖市进行分层,以探讨中国大陆健康成人及其HLA-B*35基因和其亚型总体和地区分布特征。结果:中国大陆健康成人群体HLA-B*35基因阳性率呈现北方人群高于其他地区人群;按地区分类,西北地区的HLA-B*35基因阳性率最高,华南地区阳性率较低;按省市自治区分别计算,阳性率由高到低排列分别为内蒙古自治区(11.99%)、新疆维吾尔自治区(11.76%)、宁夏回族自治区(11.75%)、青海省(11.61%)、甘肃省(11.14%),阳性率最低为广西壮族自治区(3.79%);HLA-B*3501和B*3503按地区分类时为西北最高,华南最低;按省市自治区分别统计,显示B*3501内蒙古自治区最高而广西壮族自治区最低,B*3503则表现为青海省最高,浙江省最低。结论:HLA-B*35在中国大陆地区呈现北高南低,不同地区B*35及其亚型分布,结果有助于相关疾病诊断及鉴别诊断。Objective:The aim of this study was to provide the reference for the diagnosis and differential diagnosis of related diseases,especially subacute thyroiditis by determining the general and regional distribution of the susceptible gene HLA-B*35 and its subtypes in Chinese mainland. Method:HLA high resolution typing was performed in 941 902 healthy adults in China. By classifing into 31 provinces,autonomous regions and municipalities,the overall and regional distribution characteristics of healthy adults and their HLA-B*35 genes and their subtypes in China's Mainland were determined. Results:The frequency of HLA-B *35 gene in healthy adult population in China's Mainland was higher in the northern population than that in the other regions. According to the classification of regions,the frequency of HLA-B *35 gene was the highest in Northwest China and was lower in South China. According to the calculation of provinces,municipalities and autonomous regions,the results showed that the gene frequency ranged from high to low in Inner Mongolia Autonomous Region(11.99%),Xinjiang Uygur Autonomous Region(11.76%),Ningxia Hui Autonomous Region(11.75%),Qinghai Province(11.61%)and Gansu Province(11.14%). The lowest frequency was in Guangxi Zhuang Autonomous Region(3.79%). The frequency of HLA-B* 3501 and HLA-B*3503 were the highest in Northwest China and the lowest in South China when classified by region. According to statistics of provinces and autonomous regions,the frequency of B*3501 is the highest in Inner Mongolia autonomous region and the lowest in Guangxi Zhuang autonomous region. Correspondingly,the frequency of B*3503 is the highest in Qinghai province and the lowest in Zhejiang province. Conclusion:The results showed that the distribution of HLA-B *35 in China's Mainland was high in the north and low in the south. Our study was conducted to explore the distribution of HLA-B*35 and its subtypes in different regions which is helpful for the diagnosis and differential diagnosis of related diseases.

关 键 词：亚急性甲状腺炎 HLA-B*35 HLA-B*3501 HLA-B*3503 中华骨髓库 

分 类 号：R581[医药卫生—内分泌]