不同中医证型肺鳞癌患者的化疗疗效及其中医干预疗效  

Clinical effect observation of chemotherapy and traditional Chinese medicine intervention in patients with different traditional Chinese medicine syndromes of lung squamous cell carcinoma

作　　者：周卫东 袁庆 艾瑛 谭为 万林林[5] 陈凯 何丽 甘淳 ZHOU Weidong;YUAN Qing;AI Ying;TAN Wei;WAN Linlin;CHEN Kai;HE Li;GAN Chun(Traditional Chinese Medicine deptment of Xinyu People′s Hospital,Xinyu 338000,China)

机构地区：[1]新余市人民医院中西医结合科,江西新余 338000 [2]江西省中医药高等专科学校医疗系,江西抚州 344000 [3]广东省医学科学中医科,广州 510080 [4]广东省老年医学研究所中医科,广州 510080 [5]新余市人民医院肿瘤内科,江西新余 338000 [6]江西中医药大学第二附属医院,江西南昌 330012

出　　处：《实用医学杂志》2020年第5期677-681,共5页The Journal of Practical Medicine

基　　金：江西省卫生计生委中医药科研课题项目(编号:2018A222);广东省自然科学基金项目(编号:2018A0303130315);国家自然科学基金-青年基金项目(编号:81302958)。

摘　　要：目的观察不同中医证型晚期肺鳞癌化疗疗效及其中医干预临床疗效。方法入选经确诊的初治晚期肺鳞癌患者,设单纯化疗组(A组):气阴两虚型化疗组(A1组)、瘀阻肺络型化疗组(A2组);化疗联合中医干预组(B组):化疗联合补中益气汤合沙参麦冬汤治疗组(B1组);化疗联合血府逐瘀汤治疗(B2组);给予GP方案化疗。从治疗肿瘤效果、生存质量、药物毒性反应、中医症状评分4个方面评价临床疗效。结果单纯化疗组比较:A2组较A1组有效率明显更高、不良反应发生率更低、中医临床评分明显更低(P<0.05)。化疗联合中医干预组与单纯化疗组比较:与A组相比,B组生存质量提高率及提高稳定率明显高更高,不良反应发生率更低,中医症状评分明显更低(P<0.05)。结论瘀阻肺络型肺鳞癌患者对GP化疗方案的疗效明显好于气阴两虚型。中医经辨证论治干预,能显著提高患者生存质量、减少不良反应,改善症状。Objective To observe the therapeutic effects of chemotherapy and traditional Chinese medicine(TCM)intervention on advanced lung squamous cell carcinoma with different TCM syndromes.Methods Patients diagnosed with advanced lung squamous cell carcinoma were selected.The patients of chemotherapy groups(group A)were divided into deficiency type of both Qi and Yin syndrome group(group A1)and Yu blocking the Luo group(group A2),Group A1 and group A2 received chemotherapy program of GP.Another 2 groups were set as chemotherapy combined TCM group(group B):Chemotherapy combined with Bu-Zhong-Yi-Qi decoction plus ShaShen-Mai-Dong decoction group(Group B1)and chemotherapy combined Xue-Fu-Zhu-Yu decoction group(group B2).Group B1 and group B2,received chemotherapy program of GP and dialectical application of TCM intervention.Clinical efficacy between two groups(group A1 vs.group A2,group A1 vs.group B1,group A2 vs.group B2)was evaluated by the anti-tumor effect,quality of life,drug toxicity and TCM symptom score.Results Compared with group A1,the effective rate of anti-tumor treatment with group A2 was significantly higher,the total rates of nausea and vomiting was significantly lower,and the TCM symptom score was significantly lower(P<0.05 or P<0.01).Compared with group A,improvement rate and stability improvement rate of the life quality in group B were significantly higher,the total rates of adverse reactions were significantly reduced,and TCM symptoms scores were significantly lower(P<0.05 or P<0.01).Conclusions The clinical effects of patients with lung squamous cell carcinoma with Yu blocking the Luo to chemotherapy of GP program were significantly better than that of patients with Qi and Yin deficiency.The dialectical treatment of TCM intervention in patients can significantly improve the quality of life,reduce the adverse reactions caused by chemotherapy,and improve clinical symptoms.

关 键 词：肺鳞癌 中医证型 化疗 补中益气汤合沙参麦冬汤 血府逐瘀汤 临床观察 

分 类 号：R273[医药卫生—中西医结合]