Palladium-catalyzed asymmetric allylic C–H alkylation of 1,4-dienes and glycine Schiff bases  

作　　者：Tian-Ci Wang Pu-Sheng Wang Liu-Zhu Gong 

机构地区：[1]Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry,University of Science and Technology of China,Hefei 230026,China [2]Center for Excellence in Molecular Synthesis of Chinese Academy of Sciences,Hefei 230026,China

出　　处：《Science China Chemistry》2020年第4期454-459,共6页中国科学（化学英文版）

基　　金：Ministry of Science and Technology of China(2015CB856600);the National Natural Science Foundation of China(21672197,21602214);the Chinese Academy of Sciences(XDB20020000).

摘　　要：A highly regio-and enantioselective allylic C–H alkylation of 1,4-dienes with glycine Schiff bases has been established by chiral palladium-phosphoramidite catalysis. This reaction can proceed under mild conditions and tolerate a wide scope of 1,4-dienes,delivering structurally diverse chiral β-branched α-amino acid surrogates in moderate to high yields and with high levels of regio-, Z/E-, diastereo-and enantioselectivities.A highly regio-and enantioselective allylic C–H alkylation of 1,4-dienes with glycine Schiff bases has been established by chiral palladium-phosphoramidite catalysis. This reaction can proceed under mild conditions and tolerate a wide scope of 1,4-dienes,delivering structurally diverse chiral β-branched α-amino acid surrogates in moderate to high yields and with high levels of regio-, Z/E-, diastereo-and enantioselectivities.

关 键 词：ASYMMETRIC catalysis palladium ALLYLIC C–H ALKYLATION 1 4-diene GLYCINE Schiff base 

分 类 号：O621.251[理学—有机化学]