儿童肾结石/肾钙质沉着症分子病因研究进展  

Advances in molecular etiology of nephrolithiasis/nephrocalcinosis in children

作　　者：张宁(综述)[1] 高健(审校)[2] Zhang Ning;Gao Jian(Department of Pediatrics,Weifang Medical College,Weifang 261053,China;Pediatrics of Weifang Maternal and Child Health Care Hospital,Weifang 261011,China)

机构地区：[1]潍坊医学院儿科系,261053 [2]潍坊市妇幼保健院儿科,261011

出　　处：《国际儿科学杂志》2020年第3期189-192,共4页International Journal of Pediatrics

基　　金：山东省潍坊市卫生健康委员会科研项目(wfwsjk_2019_160)。

摘　　要：儿童肾结石/肾钙质沉着症发病较为隐匿,容易引起严重的并发症。其发病机制主要是由于尿(结晶成分)过饱和与结晶抑制因子失衡所致。近年来,由于个体和(或)家族基因异常引起肾结石/肾钙质沉着症的病例逐年增加,几乎所有肾结石患儿都存在不同程度的机体代谢紊乱。研究发现,遗传因素和分子病因在其发病中所占的比例越来越高。该文对几种较常见的肾结石/肾钙质沉着症的分子病因进行综述。Nephrolithiasis/Nephrocalcinosis in children is more insidious,which is easy to cause serious complications.In recent years,the number of cases of nephrolithiasis/nephrocalcinosis caused by individual or family gene abnormality has increased.Almost all children with nephrolithiasis have different degrees of organic metabolism disorder.The molecular causes of some common nephrolithiasis/nephrocalcinosis will be summarized and analyzed in this paper.

关 键 词：儿童 肾结石 肾钙质沉着症 基因 

分 类 号：R69[医药卫生—泌尿科学]