黄芩汤中黄芩苷的大鼠在体肠吸收特性研究  

Intestinal absorption characteristics of baicalin in Huangqin Decoction in rats

作　　者：苟缙 田乙岚 杨丁雨 钟蓉 郑勇凤[1] 袁星[1] GOU Jin;TIAN Yi-lan;YANG Ding-yu;ZHONG Rong;ZHENG Yong-feng;YUAN Xing(Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)

机构地区：[1]成都中医药大学,四川成都611137

出　　处：《现代药物与临床》2020年第3期438-441,共4页Drugs & Clinic

基　　金：成都中医药大学校基金青年教师创新基金(ZRQN1706);成都中医药大学校基金医院专项(2017EL20)。

摘　　要：目的通过大鼠在体单向肠灌流实验研究黄芩汤中黄芩苷在体肠吸收特性。方法建立大鼠在体单向肠灌流模型,采用质量法计算黄芩苷吸收速率常数(Ka)和有效渗透系数(Peff)。结果黄芩汤中黄芩苷在十二指肠、空肠、回肠的吸收速率和程度都存在一定差异。其中黄芩苷在十二指肠的吸收速率显著高于空肠段,差异具有统计学意义(P<0.05),略高于回肠段但差异无统计学意义;黄芩苷在十二指肠的吸收程度明显高于空肠段且差异具有统计学意义(P<0.05),略高于回肠段但差异无统计学意义。结论黄芩汤中黄芩苷在十二指肠的吸收速度和吸收程度较好,表明黄芩汤中黄芩苷在体吸收具有肠道部位依赖特性。Objective To study the intestinal absorption characteristics of baicalin in Huangqin decoction by in vivo single intestinal perfusion test. Methods Rat model of in vivo single intestinal perfusion model was established, and the absorption rate constant(Ka) and effective osmotic coefficient(Peff) of baicalin were calculated. Results The absorption rate and degree of baicalin in duodenum, jejunum and ileum were significantly different. The absorption rate of baicalin in duodenum was significantly higher than that in jejunum, and the difference was statistically significant(P < 0.05), and it slightly higher than that in ileum, and the difference was not statistically significant. The absorption degree of baicalin in duodenum was significantly higher than that in jejunum, and the difference was statistically significant(P < 0.05), but it slightly higher than that in ileum, and the difference was not statistically significant. Conclusion The absorption rate and degree of baicalin in the duodenum of Huangqin Decoction are good, so it indicates that the absorption of baicalin in Huangqin Decoction has intestinal site-dependent characteristics.

关 键 词：黄芩汤 黄芩苷 在体肠吸收 

分 类 号：R966[医药卫生—药理学]