磁吻合环建立兔小肠侧侧吻合的实验研究  

Experimental study on establishment of side-to-side intestinal anastomosis model in rabbits with magnetic anastomosis rings

作　　者：吝怡 樊茜 朱森林 常凯曦 吉琳 牟星宜 吴玉伟 李益行 邓博 张勇[5] 马锋[2] 吕毅[1,2] 严小鹏[1,2] LIN Yi;FAN Qian;ZHU Sen-lin;CHANG Kai-xi;JI Lin;MOU Xing-yi;WU Yu-wei;LI Yi-xing;DENG Bo;ZHANG Yong;MA Feng;LYU Yi;YAN Xiao-peng(Department of Hepatobiliary Surgery,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China;National Local Joint Engineering Research Center for Precision Surgery&Regenerative Medicine,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China;Qide College,Xi'an Jiaotong University,Xi'an 710061,China;Zonglian College,Xi'an Jiaotong University,Xi'an 710061,China;Department of Thoracic Surgery,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]西安交通大学第一附属医院肝胆外科,西安710061 [2]西安交通大学第一附属医院精准外科与再生医学国家地方联合工程研究中心,西安710061 [3]西安交通大学启德书院,西安710061 [4]西安交通大学宗濂书院,西安710061 [5]西安交通大学第一附属医院胸外科,西安710061

出　　处：《医疗卫生装备》2020年第4期18-21,共4页Chinese Medical Equipment Journal

基　　金：国家自然科学基金项目(81700545);陕西省自然科学基础研究计划项目(2017JQ8021);中央高校基本科研业务费专项资金(xjj2018jchz14);西安交通大学大学生创新实验项目(GJ201910698163)。

摘　　要：目的:探讨应用磁吻合环建立兔小肠侧侧吻合的可行性。方法:设计加工适用于兔小肠侧侧吻合的子、母磁体。以10只新西兰兔为动物模型行磁压榨小肠侧侧吻合术。在胃前壁造瘘,子、母磁体经胃造瘘口依次置入小肠近端和远端内,在合适位置调整磁环至对系膜缘侧,子、母磁体相吸压榨肠壁,关闭胃造瘘口。磁环间组织受压缺血坏死后连同磁环从吻合口脱落入肠道,小肠侧侧吻合即建立,磁环最终经肠道自行排出体外。术后1月处死动物,获取吻合口标本,肉眼观察吻合口愈合情况。采用SPSS 22.0进行数据分析。结果:10只新西兰兔均顺利完成手术操作。平均手术时间为(35.30±6.41)min(范围为28~46 min),磁体排出时间为(11.70±2.21)d(范围为9~15 d)。术后1个月获取吻合口标本,肉眼观察可见小肠侧侧吻合口愈合良好。结论:磁吻合环用于兔小肠侧侧吻合具有操作简单、成功率高、吻合效果确切等优点,设计加工适用于人肠道解剖特点的磁吻合环可向临床试用推广。Objective To explore the feasibility of using magnetic anastomosis rings to establish side-to-side intestinal anastomosis in rabbits.Methods The magnetic anastomosis rings were designed and processed for side-to-side intestine anastomosis.Totally 10 New Zealand rabbits were selected for side-to-side anastomosis of the intestine by magnetic compression technique.A fistula was made in the anterior wall of the stomach.The daughter and parent magnetic rings were placed into the proximal and distal parts of the small intestine respectively through the fistula.The magnetic rings were adjusted to the edge of the mesentery side at a proper position,and then absorbed and pressed against the intestinal wall.The tissues between the magnetic anastomosis rings were compressed,ischemic and necrotic,and then dropped into the intestine together with the anastomosis rings from the anastomosis.The side-to-side anastomosis of the small intestine was established.The magnetic anastomosis rings were finally discharged out of the body through the digestive tract.One month after the operation,the animals were killed to obtain the anastomotic specimens and the anastomotic healing was observed with naked eyes.SPSS 22.0 software was used for data analysis.Results All the 10 New Zealand rabbits successfully completed the operation.The mean operation time was(35.30±6.41)min(ranging from 28 to 46 min),and magnetic anastomosis rings discharge time was(11.70±2.21)days(ranging from 9 to 15 days).One month after the operation,the anastomotic specimens were obtained,and visual observation showed that the side-to-side intestinal anastomosis healed well,and the surrounding tissue was slightly adhered.Conclusion Magnetic anastomosis rings can be used for intestine side-to-side anastomosis in rabbits,which have the advantages of simple operation,high success rate and accurate anastomotic effect.

关 键 词：磁吻合 小肠侧侧吻合 磁环 磁压榨技术 磁外科 

分 类 号：R318[医药卫生—生物医学工程] R608[医药卫生—基础医学]