脑部电阻抗有限元模型的脑膜结构仿真  

Brain EIT finite element simulation involving cerebral piamater structure

作　　者：张涛 安志伟 刘学超 章伟睿 代萌 杨滨 刘锐岗 徐灿华 ZHANG Tao;AN Zhi-wei;LIU Xue-chao;ZHANG Wei-rui;DAI Meng;YANG Bin;LIU Rui-gang;XU Can-hua(School of Biomedical Engineering,Air Force Medical University,Xi'an 710032,China)

机构地区：[1]空军军医大学军事生物医学工程学系,西安710032

出　　处：《医疗卫生装备》2020年第4期35-38,共4页Chinese Medical Equipment Journal

基　　金：国家自然科学基金项目(31771073,51837011,61771475)。

摘　　要：目的:在COMSOL软件中建立包含脑膜结构的电阻抗脑部仿真模型,探究脑膜结构对测量电位分布的影响。方法:利用一薄层结构近似代替脑膜结构,基于薄层结构切向方向的电流密度矢量分量较小、电流主要在径向传输的假设,对脑膜结构进行边界条件优化,通过计算含出血灶目标模型和含脑膜结构模型的测量电极电位值,对比脑膜结构对模型电极测量电位结果的影响程度。结果:该方法构建的模型可以用于电阻抗正问题仿真,能够降低薄层模型剖分复杂度。仿真结果表明脑膜结构对电极测量结果会产生一定影响。结论:包含脑膜结构的薄层优化脑部三维有限元模型的构建提高了脑部模型的准确性,为后续研究更加准确的脑部模型打下了基础。Objective To establish a brain EIT simulation model based on COMSOL software so as to explore the influences of cerebral pia mater structure on measuring potential distribution.Methods Cerebral pia mater structure was substituted by a thin-layer structure,and then had its boundary conditions optimized based on the hypothesis that in the thin-layer structure the tangential components of the current density vector were sufficiently small and the current was mainly transmitted at radial direction.The influences of meningeal structure on the potential results of the electrodes in the model were compared by calculating the potential values of the electrodes in the target model with hemorrhage focus and the model with meningeal structure.Results The model developed could be used for forward problem simulation of electrical impedance and reduction of the complexity of the thin-layer model,and simulation showed that cerebral pia mater structure had influences on the electrode measurement results.Conclusion A 3D thin-layer-optimized brain finite element model involving cerebral pia mater structure is constructed to enhance the accuracy of the brain model,which lays a foundation for further brain EIT researches.

关 键 词：电阻抗断层成像 脑部模型 COMSOL 薄层结构 有限元仿真 

分 类 号：R318[医药卫生—生物医学工程]