髓鞘碱性蛋白衍生多肽促进环境性恐惧记忆获得  

Myelin basic protein altered peptide promotes acquisition of contextual fear memory

作　　者：孟适秋[1] 孙成玉[1] 韩盈 时杰[1] 陆林[1,2] 李鹏[2] MENG Shiqiu;SUN Chengyu;HAN Ying;SHI Jie;LU Lin;LI Peng(National Institute on Drug Dependence,Peking University,Beijing,100191;Peking University Sixth Hospital,Peking University Institute of Mental Health,NHC Key Laboratory of Mental Health(Peking University),National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital,Beijing,100191)

机构地区：[1]北京大学中国药物依赖性研究所,北京100191 [2]北京大学第六医院北京大学精神卫生研究所国家卫生健康委员会精神卫生学重点实验室(北京大学)国家精神心理疾病临床医学研究中心(北京大学第六医院),北京100191

出　　处：《中国药物依赖性杂志》2020年第1期18-21,共4页Chinese Journal of Drug Dependence

基　　金：国家自然科学基金项目(81901352,81501158)。

摘　　要：目的:旨在探索髓鞘碱性蛋白衍生多肽对环境性恐惧记忆获得的影响。方法:合成髓鞘碱性蛋白衍生多肽MBP87-99[A^91,P^96]、MBP87-99[A^91,A^96]、MBP87-99[R^91,A^96],在大鼠环境性恐惧记忆训练开始前7 d皮下注射给药,于环境性恐惧记忆训练后第2 d进行恐惧记忆测试。结果:MBP87-99[A^91,A^96]预先单次给药增加了环境性恐惧记忆测试中大鼠的僵直行为。结论:髓鞘碱性蛋白衍生多肽MBP87-99[A^91,A^96]可促进环境性恐惧记忆获得。Objective:To investigate the effect of myelin basic protein altered peptides on acquisition of contextual fear memory. Methods:MBP87-99[A^91,P^96], MBP87-99[A^91,A^96] and MBP87-99[R^91,A^96] were synthesized, and injected subcutaneously into rats seven days before training of contextual fear memory. Contextual fear memory was tested 24 hours after training. Results:A single dose of MBP87-99[A^91,A^96] increased freezing behavior of rats during contextual fear memory test. Conclusion:Myelin basic protein altered peptide, MBP87-99[A^91,A^96], promoted acquisition of contextual fear memory.

关 键 词：髓鞘碱性蛋白衍生多肽 环境性恐惧记忆 获得 

分 类 号：R338.64[医药卫生—人体生理学]