BDNF基因多态性对恐惧记忆获得和消退的影响研究  

The effect of BDNF gene polymorphism on fear acquisition and extinction in humans

作　　者：邓佳慧[1] 阙建宇 师乐[1] DENG Jiahui;QUE Jianyu;SHI Le(Peking University Sixth Hospital,Peking University Institute of Mental Health,NHC Key Laboratory of Mental Health(Peking University),National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital),Beijing,100191)

机构地区：[1]北京大学第六医院北京大学精神卫生研究所国家卫生健康委员会精神卫生学重点实验室(北京大学)国家精神心理疾病临床医学研究中心(北京大学第六医院),北京100191

出　　处：《中国药物依赖性杂志》2020年第1期22-28,共7页Chinese Journal of Drug Dependence

基　　金：国家自然科学基金(81600925);北京市科学技术委员会项目(Z181100001718051)。

摘　　要：目的:探索脑源性神经营养因子(BDNF)rs6265位点基因多态性与条件性恐惧记忆获得、消退及复燃的关系。方法:招募符合入组和排除标准的90名18-30岁的汉族健康男性,采集人口学资料、血液样本并进行恐惧记忆的学习、消退及测试。采用MassARRAY基因分型方法确定受试者在BDNF基因位点rs6265的单核苷酸多态性,采用方差分析探索BDNF rs6265位点与恐惧记忆学习和消退的关联。结果:BDNF rs6265位点的三种基因型CC、CT、TT对恐惧记忆获得、消退、自发恢复和复燃的影响无显著差异(P>0.05)。结论:BDNF rs6265多态性位点不影响恐惧记忆的获得、消退和表达。Objective:To explore the relationship between brain derived neurotrophic factor(BDNF) rs6265 polymorphism and fear memory acquisition, extinction and expression in humans. Methods:Ninety healthy Chinese Han male participants aged 18-30 were recruited for demographic data and blood sample collection, and fear memory learning, extinction and test. The single nucleotide polymorphism of BDNF rs6265 was determined by MassARRAY genotyping, and the association between BDNF rs6265 and fear memory learning and extinction was explored by ANOVA. Results:The three genotypes of BDNF rs6265 polymorphism had no significant effect on fear acquisition, extinction, spontaneous recovery and reinstatement(P>0.05). Conclusion:The polymorphism of BDNF rs6265 does not affect the acquisition, extinction and expression of fear memory in humans.

关 键 词：恐惧记忆学习 消退 脑源性神经营养因子 基因多态性 

分 类 号：R338.64[医药卫生—人体生理学]