阿片类成瘾孕妇的围产儿预后分析  

Analysis of perinatal prognosis of pregnant women with opioid addiction

作　　者：林丽苹 张雪芹 LIN Liping;ZHANG Xueqin(Xiamen Maternal and Child Health Hospital,Xiamen,361003)

机构地区：[1]厦门市妇幼保健院,厦门361003

出　　处：《中国药物依赖性杂志》2020年第1期59-63,共5页Chinese Journal of Drug Dependence

摘　　要：目的:分析阿片类成瘾孕妇的围产儿预后情况。方法:收集厦门市妇幼保健院2014年1月-2018年10月87例阿片类成瘾孕产妇分娩资料,比较阿片类成瘾孕产妇与同时段一般孕产妇基本资料及不良妊娠结局发生差异,分析影响围产儿不良预后的危险因素。所有数据使用SPSS22.0统计学软件分析。结果:本次研究的实验组87例和对照组9964例产妇的年龄、孕次、产次、孕周及产后出血无显著差异(P>0.05),RBC、HGB、MCV、PLT及MPV差异有统计学意义(P<0.05),实验组新生儿早产、低出生体重、早期新生儿死亡、死胎、新生儿戒断综合征及新生儿异常症状/体征发生率均显著高于对照组,组间差异有统计学意义(P<0.001);87例阿片类成瘾孕妇中非治疗组新生儿戒断综合征发生率高于治疗组组,组间差异有统计学意义(P<0.05);吸毒量、吸毒时间、成瘾程度是阿片类成瘾孕妇的围产儿不良预后的危险因素。结论:阿片类成瘾孕妇不良妊娠结局发生率较高,接受治疗可有效降低新生儿戒断综合征的发生,对此类高危孕妇应给予足够的重视,加强监测和治疗,确保母婴安全。Objective:To analyze the perinatal prognosis of pregnant women with opioid addiction. Methods:Data of 87 opioid addicted pregnant and lying-in women from January 2014 to October 2018 in Xiamen Maternal and Child Health Hospital were collected. The differences of basic data and adverse pregnancy outcomes between opioid addicted pregnant and lying-in women and general pregnant and lying-in women in the same period were compared, and the risk factors affecting the adverse prognosis of perinatal infants were analyzed. All data were analyzed by SPSS22.0 statistical software. Results:There were no significant differences in age, pregnancy times, parity, gestational weeks and postpartum hemorrhage between 87 cases in the experimental group and 9964 cases in the control group(P>0.05). There were significant differences in RBC, HGB, MCV, PLT and MPV(P<0.05). Premature birth, low birth weight, early neonatal death, stillbirth, neonatal withdrawal syndrome and abnormal neonatal symptoms/signs in the experimental group were significantly different(P<0.05). Among the 87 pregnant women with opioid addiction, the incidence of neonatal withdrawal syndrome in the non-treatment group was higher than those in the treatment group(P<0.05). The risk factors of adverse perinatal prognosis in pregnant women with opioid addiction were the amount, time and degree of addiction(P<0.05). Conclusion:The incidence of adverse pregnancy outcomes in pregnant women with opioid addiction is high. Treatment can effectively reduce the incidence of neonatal withdrawal syndrome. Adequate attention should be paid to such high-risk pregnant women, and monitoring and treatment should be strengthened to ensure the safety of mothers and infants.

关 键 词：阿片类药物 成瘾 孕妇 围产儿 

分 类 号：R714.7[医药卫生—妇产科学]