乳腺癌辅助化疗后重度骨髓抑制中医证候的聚类研究  

Traditional Chinese medicine syndromes of severe myelosuppression after adjuvant chemotherapy for breast cancer:A cluster analysis

作　　者：石传科[1] 严志登[1] 罗明[1] 徐丹[1] 汪峰[1] SHI Chuanke;YAN Zhideng;LUO Ming;XU Dan;WANG Feng(Zhongshan Hospital of Traditional Chinese Medicine,Guangzhou University of Chinese Medicine,Zhongshan 528400,Guangdong,China)

机构地区：[1]广州中医药大学附属中山市中医院,广东中山528400

出　　处：《湖南中医杂志》2020年第3期11-13,共3页Hunan Journal of Traditional Chinese Medicine

摘　　要：目的:收集乳腺癌辅助化疗后重度骨髓抑制患者的四诊信息,进行聚类分析,确立其中医证候,以指导辨证治疗。方法:纳入2016年9月至2018年9月于我院乳腺专科行辅助化疗后出现3、4度骨髓抑制的患者34例,采集其中医四诊信息,建立数据库,行聚类统计分析,探究其所属证候。结果:该类患者证候群聚为两类时表现为气血两虚证和脾肾亏虚证;对聚类结果再截取为一类时表现为气虚证。结论:乳腺癌辅助化疗后重度骨髓抑制急症的证型为气虚证,参考《中医量化诊断》后认为,该气虚证为气虚之至极证候。Objective:To investigate the traditional Chinese medicine(TCM)syndromes of severe myelosuppression through a cluster analysis of the information obtained by four diagnostic methods from the patients with severe myelosuppression after adjuvant chemotherapy for breast cancer,and to guide syndrome differentiation and treatment.Methods:A total of 34 patients with grade 3 or 4 myelosuppression after adjuvant chemotherapy in Department of Breast Surgery in our hospital from September 2016 to September 2018 were enrolled,and the information obtained by four diagnostic methods was collected to establish a database.A cluster analysis was performed to investigate related TCM syndromes.Results:When the syndromes were clustered into two categories,such patients had the manifestations of Qi-blood deficiency and spleen and kidney deficiency;when these results were clustered into one category,the patients had the manifestation of Qi deficiency syndrome.Conclusion:Severe myelosuppression after adjuvant chemotherapy for breast cancer has the main syndrome type of Qi deficiency syndrome,and with reference to Quantitative TCM Diagnosis,this Qi deficiency syndrome is the extreme of Qi deficiency.

关 键 词：乳腺癌 重度骨髓抑制 中医证候 聚类分析 

分 类 号：R273.053[医药卫生—中西医结合] R273.06[医药卫生—中医肿瘤科]