脉冲给药系统的研究进展  

Research Progress of Pulsatile Delivery System

作　　者：颜红 李欣 徐伟娜 刘林 翟光喜[1] YAN Hong;LI Xin;XU Wei-na;LIU Lin;ZHAI Guang-xi(School of Pharmaceutical Science,Shandong University,Ji'nan 250012 China;Shandong Provincial Key Laboratory of Chemical Drugs,Shandong Academy of Pharmaceutical Sciences,Ji'nan 250101,China)

机构地区：[1]山东大学药学院,山东济南250012 [2]山东省药学科学院山东省化学药物重点实验室,山东济南250101

出　　处：《药物生物技术》2020年第1期91-94,共4页Pharmaceutical Biotechnology

摘　　要：脉冲给药系统是根据时辰药理学与时辰治疗学特点研究而设计的一种新型迟释给药制剂。文章查阅了近几年国内外相关文献,阐述了脉冲给药系统的释药机制,包括生物化学刺激(胃肠道酸碱度、酶敏感度、葡萄糖敏感度等),物理化学刺激(声波、磁场、电场、温度等),膨胀爆破释药机制以及定时脉冲塞胶囊释药机制,并总结了基于各类释药机制的脉冲释药系统在药剂学中的应用研究进展。The pulsatile delivery system was a novel delayed-release drug delivery preparation designed according to the characteristics of time pharmacology and time treatment.In this paper,the relevant literatures at home and abroad in recent years was reviewed,and the drug release mechanism of pulsed drug delivery systems was explained,including biochemical stimulation(gastrointestinal pH,enzyme sensitivity,glucose sensitivity,etc.),physicochemical stimulation(sonic,magnetic,Electric field,temperature,etc.),expansion and blasting release mechanism and timing pulse capsule release mechanism.On the basis of expounding the drug release mechanism of pulsed drug delivery system,the research progress of pulse preparation based on various drug release mechanisms was summarized.

关 键 词：脉冲给药系统 时辰药理学 时辰治疗学 释药机制 生物化学刺激 物理化学刺激 膨胀爆炸释药 定时脉冲塞胶囊 

分 类 号：R969.3[医药卫生—药理学]