阿昔洛韦-G复合物超分子凝胶自组装行为研究  

Self-assembly behavior of aciclovir-G complex supramolecular gel

作　　者：吕宏亮 冯青[1] 张燚曼 王光月 吴冰 于智莘[1] LYU Hongliang;FENG Qing;ZHANG Yiman;WANG Guangyue;WU Bing;YU Zhixin(College of Pharmacy,Changchun University of Chinese Medicine,Changchun 130117,China)

机构地区：[1]长春中医药大学药学院,长春130117

出　　处：《长春中医药大学学报》2020年第2期281-285,共5页Journal of Changchun University of Chinese Medicine

基　　金：吉林省教育厅“十三五”科学技术项目(JJKH20181404ZC);吉林省教育厅“十三五”科学技术项目(JJKH20190471KJ);吉林省科技发展计划项目(20180201086YY)。

摘　　要：目的探究基于阿昔洛韦(A)-吡啶环衍生物(G)构建超分子凝胶的性能及自组装机制。方法通过1H NMR,SEM,傅立叶变换红外(FT-IR)光谱和广角X射线衍射(WAXD)确定了阿昔洛韦凝胶分子结构,研究了其5种凝胶的自组装行为。结果通过将水中A和G的摩尔比从高于临界凝胶化浓度(CGC)0.1wt%的1:3变为3:1来调节3D形态。A和G的摩尔比使干凝胶在SEM下显示棒状、片状不同结构。FT-IR光谱和WAXD图谱证实超分子复合物通过-C=O… HN-之间的分子间氢键结合。干凝胶的形态和WAXD图谱对于不同的复合物是不同的,表明A-G复合物中不同的自组装模式。结论阿昔洛韦及吡啶环衍生物在水溶液中可以发生基于氢键的自组装凝胶化,为未来药物材料的开发提供参考和理论依据。Objective To investigate the properties and self-assembly mechanisms of supramolecular gels based on acyclovir (A)-pyridine ring derivatives (G).Methods The Acyclovir gel molecular structures were confirmed by 1H NMR,SEM,Fourier transform infrared (FT-IR) spectroscopy and wide angle X-ray diffraction (WAXD),their self-assembly behavior of five kinds of gels were investigated.Results The 3D morphologies were tuned by changing the molar ratio of A and G in water from 1:3 to 3:1 above the critical gelation concentrations (CGC) of 0.1 wt%.The xerogels showed rod,sheet structures as observed under SEM depending on the molar ratios of A and G.FT-IR spectroscopy and WAXD studies confirmed that the supramolecular complexes through intermolecular hydrogen-bonding between-C=O...H-N-.The morphology and WAXD patterns of the xerogels were different for different complexes indicating different modes of self-assembly in A-G complexes.Conclusion Acyclovir and pyridine ring derivative can gel based on self-assembly of hydrogen bonding in aqueous solution,which provides a reference and theoretical basis for the development of drug materials in the future.

关 键 词：阿昔洛韦 吡啶环衍生物 自组装 

分 类 号：TQ460[化学工程—制药化工]