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作 者:Yueying Zhang Yiliang Ding
出 处:《Molecular Plant》2020年第2期184-186,共3页分子植物(英文版)
基 金:supported by the Biotechnology and Biological Sciences Research Council[BB/L025000/1];a European Commission Horizon 2020 European Research Council Starting Grant[680324].
摘 要:Gene expression involves a three-step process including transcribing precursor messenger RNAs(pre-mRNAs)from DNA templates by RNA polymerase II(Pol II),processing pre-mRNAs into mature mRNAs,and translating mature mRNAs into proteins(Bentley,2014).The maturation of pre-mRNAs entails 5′end capping,pre-mRNA splicing,3′end processing,and RNA modification(Bentley,2014).Pre-mRNA splicing is a two-step transesterification reaction,catalyzed by the spliceosome in recognizing various sequence motifs in pre-mRNAs including 5′and 3′splice sites,branch points,polypyrimidine tracts,and other splicing regulatory elements(Herzel et al.,2017).
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