母亲乙肝病毒感染状况对其子代疫苗接种效果影响的分析  

Analysis of the impact of maternal hepatitis B virus infection on vaccination effect of the offspring

作　　者：李本科 纪民 赵旭 LI Benke;JI min;ZHAO Xu(Intervention Department of Dalian Sixth People′s Hospital,Dalian,Liaoning 116031,China)

机构地区：[1]辽宁省大连市第六人民医院介入科,辽宁大连116031

出　　处：《公共卫生与预防医学》2020年第2期138-140,共3页Journal of Public Health and Preventive Medicine

摘　　要：目的探究母亲乙肝病毒(hepatitis B virus,HBV)感染状况对其子代乙肝疫苗接种效果的影响。方法选取2017—2019年大连市第六人民医院接受治疗的86对HBV感染母亲和新生儿为研究对象,按照乙肝疫苗应答反应强弱将所有患者分为两组,其中观察组为无/弱应答,对照组为强应答,比较两组母亲的乙肝病毒感染情况,使用多因素Logisitic回归分析子代疫苗接种效果的影响因素。结果观察组母亲HBV DNA阳性率高于对照组,HBV DNA以高载量为主,HBeAg以低水平为主,对照组母亲HBV DNA以低载量为主,HBeAg水平分布平均,差异有统计学意义(P<0.05);观察组HBV感染模式为“HBsAg(+)、HBeAg(+)、抗-HBc(+)”共14例(51.85%),“HBsAg(+)、抗-HBe(+)、抗-HBc(+)”共11例(40.74%),对照组分别有27例(45.76%)、25例(42.37%)、7例(11.86%),差异有统计学意义(P<0.05);多因素Logisitic回归分析显示,HBV DNA阳性、HBV DNA高载量、HBeAg阳性、HBeAg低水平是子代疫苗应答反应弱的危险因素。结论乙肝病毒感染母亲HBV DNA阳性、HBV DNA高载量、HBeAg阳性、HBeAg低水平是子代疫苗应答反应弱的危险因素,临床上应该加以重视。Objective To explore the impact of maternal hepatitis B(HBV)virus infection status on the vaccination effect of the offspring.Methods Eighty-six pairs of HBV-infected mothers and newborns who were treated in Dalian Sixth People′s Hospital from 2017 to 2019 were selected as the research subjects.According to the strength of the hepatitis B vaccine response,all patients were divided into two groups,the observation group(none or weak response)and the control group(strong response).Hepatitis B virus infection was compared between the mothers of the two groups,and multivariate logistic regression was used to analyze the influencing factors of vaccination effect of the offspring.Results The positive rate of HBV DNA in mothers of the observation group was higher than that in the control group.HBV DNA was mainly at high load and HBeAg was at low level.The HBV DNA of the control group was mainly at low load,while the distribution of HBeAg was close.The difference was statistically significant(P<0.05).HBV infection pattern in the observation group was"HBsAg(+),HBeAg(+),anti-HBc(+)"in 14 cases(51.85%),"HBsAg(+),anti-HBe(+),anti-HBc(+)"in 11 cases(40.74%),while there were 27 cases(45.76%),25 cases(42.37%),and 7 cases(11.86%),respectively,in the control group.The difference was statistically significant(P<0.05).Multivariate logisitic regression analysis showed that HBV DNA positivity,HBV DNA high load,HBeAg positivity,and low HBeAg levels were risk factors for weak response of the offspring vaccination.Conclusion HBV DNA positivity,high HBV DNA load,HBeAg positivity,and low HBeAg levels in HBV-infected mothers were risk factors for weak response of the offspring to vaccines,which should be paid attention to in clinic.

关 键 词：乙肝病毒感染 子代 疫苗接种 影响因素 

分 类 号：R183[医药卫生—流行病学] R512.6[医药卫生—公共卫生与预防医学]