隔药灸“翻胃”穴治疗糖尿病胃轻瘫及对血浆胃动素、血清胃泌素的影响  

Effect of herb-partitioned moxibustion at fanwei point on plasma motilin and serum gastrin in patients of diabetic gastroparesis

作　　者：孟娜 石志敏 MENG Na;SHI Zhi-min(Second Department of Endocrinology,Tangshan Gongren Hospital,Tangshan 063000,Hebei Province,China;Department of Spleen and Stomach Disorders,Tangshan TCM Hospital,Tangshan 063000,Hebei Province)

机构地区：[1]唐山市工人医院内分泌二科,河北唐山063000 [2]唐山市中医医院脾胃病科,河北唐山063000

出　　处：《中国针灸》2020年第4期361-364,共4页Chinese Acupuncture & Moxibustion

基　　金：2017年度河北省中医药管理局中医药类科研计划课题:2017198。

摘　　要：目的:探讨隔药灸"翻胃"穴治疗脾胃虚弱、湿浊内蕴型糖尿病胃轻瘫的临床疗效及作用机制。方法:将134例糖尿病胃轻瘫患者随机分为观察组和对照组,每组67例。观察组给予隔药灸"翻胃"穴治疗,每次40 min,每日1次,每周5次;对照组给予口服盐酸伊托必利片治疗,每次50mg,每日3次,两组均治疗6周。观察两组患者治疗前后胃轻瘫主要症状指数量表(GCSI)评分、4h胃排空率、中医症状积分和血浆胃动素、血清胃泌素水平,并评定两组临床疗效。结果:治疗后,两组患者GCSI各项评分、中医症状积分及血浆胃动素、血清胃泌素水平均较治疗前下降(P<0.05),且观察组低于对照组(P<0.05);4 h胃排空率均较治疗前升高(P<0.05),且观察组高于对照组(P<0.05)。观察组总有效率为92.5%(62/67),高于对照组的74.6%(50/67,P<0.05)。结论:隔药灸"翻胃"穴能改善糖尿病胃轻瘫患者的临床症状及胃排空率,可能与调节血浆胃动素、血清胃泌素水平有关。Objective To explore the clinical therapeutic effect of herb-partitioned moxibustion at fanwei point in patients of diabetic gastroparesis differentiated as spleen and stomach deficiency and retention of turbid dampness as well as its effect mechanism.Methods A total of 134 patients with diabetic gastroparesis were randomized into an observation group and a control group,67 cases in each one.In the observation group,herb-partitioned moxibustion at fanwei point was adopted,40 min each time,once a day for 5 times a week.In the control group,itopride hydrochloride tablets were prescribed for oral administration,50 mg each time,three times a day.A total of 6 weeks of treatment was required in the two groups.Before and after treatment,the gastroparesis cardinal symptom index(GCSI)scores,4-hour gastric emptying rate,TCM symptom score,as well as the levels of plasma motilin and serum gastrin were observed in the patients of the two groups.Additionally,the clinical therapeutic effect was evaluated in the two groups.Results After treatment,the score of every item of GCSI,TCM symptom scores and the levels of plasma motilin and serum gastrin were all reduced as compared with those before treatment in the patients of the two groups(P<0.05),and those in the observation group were lower than the control group(P<0.05).Regarding 4-hour gastric emptying rates,which were increased as compared with those before treatment in the two group(P<0.05),and the rate in the observation group was higher remarkably than that in the control group(P<0.05).The total effective rate was 92.5%(62/67)in the observation group,higher than 74.6%(50/67)in the control group(P<0.05).Conclusion Herb-partitioned moxibustion at fanwei point relieves the clinical symptoms in the patients with diabetic gastroparesis and increases the gastric emptying rate,which is probably related to the regulation of the levels of plasma motilin and serum gastrin.

关 键 词：2型糖尿病 胃轻瘫 隔药灸 艾灸 胃动素 胃泌素 

分 类 号：R246.1[医药卫生—针灸推拿学]