复方益肝颗粒中活性成分的提取工艺研究  

Study on the extraction process of active components in compound Yigan granules

作　　者：陈东红 黄阿贤 CHEN Donghong;HUANG Axian(Fujian Pharmaceutical Machinery Joint Purchasing Center,Fuzhou,Fujian Province,350001;Fujian Zhangzhou Meilide Bioengineering Co.,Ltd,Zhangzhou,Fujian Province,363600,China)

机构地区：[1]福建省药械联合采购中心,福建福州350001 [2]福建漳州美利得生物工程公司,福建漳州363600

出　　处：《吉林医药学院学报》2020年第3期174-176,共3页Journal of Jilin Medical University

摘　　要：目的研究复方益肝颗粒处方中主药的活性成分提取工艺。方法以苦参碱为指标成分,采用正交试验筛选优化提取工艺条件。结果采用薄层扫描法测定苦参碱含量,在1.17~5.83μg范围内与峰面积的线性良好。正交试验结果显示,提取苦参碱的水用量、提取时间、提取次数3个因素对提取工艺无明显影响。结论该方法简便可行,可为该制剂的工艺条件及质量控制提供参考。Objective To study the extraction technology of active components in the prescription of compound Yigan granules.Methods With Matrine as the index component,the extraction conditions were optimized by orthogonal test.Results The content of matrine was determined by TLC scanning.The linearity between the content and peak area was good in the range of 1.17~5.83μg.The orthogonal test results showed that the amount of water,extraction time and extraction times had no significant effect on the extraction process.Conclusion The method is simple and feasible,which can provide reference for the technological conditions and quality control of the preparation.

关 键 词：复方益肝颗粒 提取工艺 苦参碱 薄层扫描 

分 类 号：R282.77[医药卫生—中药学]