环状非编码RNA在间充质干细胞成骨向分化中作用的研究进展  

Research progress on circular RNA in the osteogenic differentiation of mesenchymal stem cells

作　　者：杨叶青[1,2] 陈明 吴补领[1,2] Yang Yeqing;Chen Ming;Wu Buling(Dept.of Stomatology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;School of Stomatology,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院口腔科,广州510515 [2]南方医科大学口腔医学院,广州510515

出　　处：《国际口腔医学杂志》2020年第3期257-262,共6页International Journal of Stomatology

基　　金：国家自然科学基金(81870755);国家自然科学基金(81600882)。

摘　　要：间充质干细胞是一类具有自我更新和多向分化潜能的成体干细胞。随着对间充质干细胞研究的不断深入,对间充质干细胞的生物学特性、分化能力及临床应用有了进一步认识。环状RNA(circRNA)是在真核细胞中广泛存在且多样的内源性非编码RNA,形成共价、闭合、连续稳定的环状结构,能够发挥微小RNA分子海绵作用,调控基因转录和选择性剪接。多项研究已经证实circRNA在间充质干细胞成骨向分化过程中发挥了重要作用,是细胞分化的重要调控靶点,参与维持细胞分化特性,并且从不同的角度和不同水平研究了circRNA的调控机制。本文对目前circRNA在不同间充质干细胞成骨向分化过程中的相关研究进行综述。Mesenchymal stem cells(MSCs)are adult stem cells with self-renewal and multi-directional differentiation proficiency.The increasing number of studies on MSCs has allowed people to further understand their biological characteristics,differentiation ability and clinical application.Circular RNA(circRNA)is a kind of universal and diverse endogenous non-coding RNA,which is widely found in eukaryotic cells.The circular structure is covalently closed,continuous and stable.circRNA has many functions,such as microRNA sponges and regulators of alternative splicing and gene expression.Studies have shown that circRNA is a vital regulated target that plays an important role in the osteogenic differentiation of MSCs to maintain the characteristics of differentiation.This article reviews the current research on the effects of circRNA on the osteogenic differentiation of MSCs.

关 键 词：间充质干细胞 成骨向分化 环状RNA 

分 类 号：Q254[生物学—细胞生物学]