Comparison of long-term clinical outcomes after percutaneous coronary intervention between in-stent restenosis and de novo chronic total occlusion  

作　　者：CHAI Ren-jie ZHANG Bin LIU Ning-ning ZHOU Yi LUO Bing-zheng HUANG Ze-han 

机构地区：[1]Department of Cardiology,the Second Affiliated Hospital of Guangzhou Medical University,Institute of Cardiovascular Disease,Guangzhou 510260,Guangdong [2]Department of Cardiology,Guangdong Cardiovascular Institute,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510180,China

出　　处：《South China Journal of Cardiology》2020年第1期6-11,共6页岭南心血管病杂志（英文版）

摘　　要：Background The occurrence of in-stent restenosis(ISR)coronary chronic total occlusion(CTO)is presently increasing. However,there were few data related to the long-term clinical outcomes after percutaneous coronary intervention(PCI)between ISR CTO and de novo CTO. Methods A total of 435 CTO patients who had attempted PCI between Jan 2013 and November 2017 were screened for inclusion in this study. The Kaplan-Meier method was applied to estimate event-free survival and the log-rank test to compare long-term outcome. Cox regression analysis was used to identify associations between adverse events and risk factors. Results There were84 ISR CTO cases and 351 de novo CTO cases in this study. Successful revascularization was achieved similar between ISR CTO group and de novo CTO group(84.5% vs. 87.2%,P=0.592). The prevalence of MACE[17.9% vs. 9.1%;hazard ratio(HR):2.323;95% confidence interval(CI)1.233-4.37;P=0.004]and TLR(8.3% vs. 3.4%;HR:2.627;95% CI 1.05-6.53;P<0.016)were higher in the ISR CTO group,during the 2-year follow-up. Conclusions The procedural success rate of ISR CTO achieved was comparable to that of de novo CTO in the contemporary practice. But the long-term clinical outcome was significantly worse in term of major adverse cardiac events and target lesion revascularization.

关 键 词：in⁃stent restenosis coronary chronic total occlusion PROGNOSIS 

分 类 号：R54[医药卫生—心血管疾病]