围绝经期肥胖患者中医证素与体脂参数的关系研究  

Study on TCM syndrome factor and body fat parameters in perimenopausal period obesity patients

作　　者：范慧娟 丁珊珊[1,2,3] 赵强 高碧珍[1,2,3] 陈淑娇 FAN Hui-juan;DING Shan-shan;ZHAO Qiang;GAO Bi-zhen;CHEN Shu-jiao(Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;Fujian Key Laboratory of TCM Health State,Fuzhou 350122,China;Fujian Province Collaborative Innovation Center of Chinese Medicine Health Management 2011,Fuzhou 350122,China;Zhejiang Changshan County People’s Hospital,Quzhou 324200,China;The Third People’s Hospital Affiliated to Fujian University of Chinese Medicine,Fuzhou 350122,China)

机构地区：[1]福建中医药大学,福州350122 [2]福建省中医健康状态辨识重点实验室,福州350122 [3]福建省2011中医健康管理协同创新中心,福州350122 [4]浙江常山县人民医院,衢州324200 [5]福建中医药大学附属第三人民医院中医健康管理中心,福州350122

出　　处：《中华中医药杂志》2020年第1期338-343,共6页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金面上项目(No.81473595)。

摘　　要：目的:通过对围绝经期肥胖患者中医证素分布与体脂参数之间的关系研究,为临床围绝经期肥胖中医诊治提供生物学测量依据。方法:收集238例围绝经期肥胖患者的四诊信息及体脂参数结果,依据证素辨证分为兼杂证素组和非兼杂证素组,对两组间的体脂参数进行比较。结果:腹腔内脏脂肪面积(VFA)与年龄、体质量、BMI、腰围成正相关(P<0.05,P<0.01);腹腔皮下脂肪面积(SFA)与体质量、BMI、腰围成正相关(P<0.01);VFA/SFA与年龄成正相关(P<0.05)。围绝经期肥胖的病位以肝、脾、肾、胞宫为主,实证病性以痰、湿、气滞、热、血瘀、阳亢为主,虚证病性以阴虚、气虚、血虚、阳虚为主。中医证素与体脂参数:①病位:兼杂肝、肾证素患者年龄较非兼杂该证素者大(P<0.05,P<0.01),而兼杂胞宫证素者在年龄、腰围、VFA、SFA比非兼杂胞宫证素者小(P<0.05,P<0.01)。②实证病性:兼杂阳亢证素者年龄、BMI较非兼杂阳亢证素者大(P<0.01),兼杂血瘀证素者年龄较非兼杂血瘀证素者小(P<0.01)。③虚证病性:兼杂阴虚证素者年龄较非兼杂阴素证素者大(P<0.01),兼杂气虚证素者的VFA较非兼杂气虚证素者大(P<0.05)。结论:围绝经期肥胖患者兼杂肝、肾、阳亢、阴虚证素的年龄高于非兼杂该证素者,兼杂气虚证素者的VFA较非兼杂气虚证素者大。围绝经期肥胖患者的脂肪异位沉积与年龄、气虚证素相关,脂肪异位沉积的发生可能是围绝经期肥胖兼杂气虚证素的生物学基础。Objective:To provide a biological measurement basis for clinical diagnosis and treatment of perimenopausal obesity by studying the relationship between TCM syndrome distribution and body fat parameters in perimenopausal obese patients.Methods:The data of four diagnoses and body fat parameters of 238 patients with perimenopausal obesity were collected.According to the dialectical syndrome differentiation method,they were divided into phase syndrome group and non-phase syndrome group,and the body fat parameters between the two groups were compared.Results:The visceral fat area (VFA) was positively correlated with age,body weight,BMI and waist circumference (P<0.05,P<0.01).The subcutaneous fat area (SFA) was positively correlated with body weight,BMI and waist circumference (P<0.01);VFA/SFA was positively correlated with age (P<0.05).The peri-menopausal obesity is mainly caused by liver,spleen,kidney and uterus.The actual pathological condition is phlegm,dampness,qi stagnation,heat,blood stasis and hyperactivity of yang.The deficiency syndrome is yin deficiency,qi deficiency,blood deficiency,and yang deficiency.TCM syndrome and body fat parameters:①Disease position:patients with mixed liver and complicated kidneys are older than those with the same syndrome (P<0.05,P<0.01),and those who are also heterozygous syndrome The age,waist circumference,VFA,and SFA were smaller than those of the non-particulates (P<0.05,P<0.01).②Empirical disease:The age and BMI of patients with mixed hyperactivity of yang were larger than those with non-complexity (P<0.01),and the age of patients with mixed blood stasis syndrome was smaller than that of non-mixed hyperactivity (P<0.01).③Deficiency syndrome:The age of yin deficiency was larger than that of non-complex (P<0.01),and the visceral fat area of those with qi deficiency was larger than that of non-complex (P<0.05).Conclusion:Perimenopausal obese patients with mixed liver,kidney,hyperactivity of yang,and yin deficiency syndrome are higher than those who are not mixed with the

关 键 词：围绝经期 肥胖 证素 体脂参数 脂肪异位沉积 

分 类 号：R259[医药卫生—中西医结合]