我院18岁以下患者出院带抗肿瘤药物情况及安全风险初探  

Investigation on Status of Chemotherapy Drugs for Discharged Patients Under 18 Years Old in Our Hospital and Its Potential Risks

作　　者：刘芳[1,3] 常青[2] 朱珠 范倩倩[1] 余波[4,5] LIU Fang;CHANG Qing;ZHU Zhu;FAN Qian-qian;YU Bo(Department of Pharmacy,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing,China;Department of Medical Administration,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing,China;Beijing Luhe Hospital,Beijing 100069,China;Department of Pharmacy,Fudan University Shanghai Cancer Center 9 Shanghai 200032,China;Department of Cancer,Shanghai Medical College of Fudan University,Shanghai 200032,China)

机构地区：[1]中国医学科学院北京协和医院药剂科,北京100730 [2]中国医学科学院北京协和医院医务处,北京100730 [3]首都医科大学附属北京路河医院,北京100069 [4]复旦大学附属肿瘤医院药剂科,上海200032 [5]复旦大学上海医学院肿瘤学系,上海200032

出　　处：《中国药学杂志》2020年第6期473-479,共7页Chinese Pharmaceutical Journal

基　　金：中华医学会临床药学分会-吴阶平医学基金会科研专项基金项目资助(320.6750.19090-30)。

摘　　要：目的以我院18岁以下患者出院带抗肿瘤药物的基拙数据,调研未成年患者出院时携带抗肿瘤药与居家使用的现状和风险。方法采用回顾性研究方法,对我院病区2017年12月1日至2018年5月31日间出院的18岁以下患者含抗肿瘤药物相关1955条医嘱进行统计分析。结果采样期间,18岁以下出院带抗肿瘤药的患者共计153人,涉及带抗肿瘤药共计30种;医嘱中存在剩余药量的药物17种。结论本研究发现,出院时带抗肿瘤药物延续治疗很有必要;本研究中需冷藏和需阴凉处保存的药物各1种,在旅途中不易达到保存条件;在总共1955条医嘱中,有898条医嘱存在剩余量问题,在肿瘤患者和非肿瘤患者中剩余量条目数占比分别为57.11%和7.09%;出院后携带和服用抗肿瘤药物过程中的安全风险,尚未被关注,应加强对未成年患者及其监护人的用药辅导。OBJECTIVE To investigate the actual data of chemotherapy drugs for discharged patients under 18 years old in our hospital,and to firstly provide the real status and risk of chemotherapy drugs during carrying and use at home.METHODS A retrospective research was adopted to statistically analyze 1955 discharged orders of the patients,under the age of 18,with chemotherapy drugs in our hospital from December 1,2017 to May 31,2018.RESULTS During the sampling period,there were 153 patients with chemotherapy drugs discharged under the age of 18 years old.Thirty kinds of chemotherapy drugs were involved,and 17 drugs with the remaining drug amount regarding to its dosage regimen.CONCLUSION It was found that it is common and necessary to continue treatment with chemotherapy drugs after discharged.One drug needs to be refrigerated and the other needs to be kept in a shade place,which is difficult to reach the preservation conditions during the journey.There is a residual amount of medications over its usage for young patients,of the total 1955 medical orders,898 have the problem of residual amount,which account for 57.11%in cancer patients and 7.09%in non-cancer patients,respectively.For pharmacists,it is time exploring medication education and follow-up for discharged patients,especially for young patients and their guardians.

关 键 词：抗肿瘤药物 细胞毒性药 18岁以下 未成年 剩余量 安全 风险 

分 类 号：R969.3[医药卫生—药理学]