法半夏产业化生产的“减毒-存效”研究  

Reducing toxicity and preserving efficacy of Rhizoma Pinellinae praeparata in industrial production

作　　者：杨紫莹 王芳静 金传山[1,2,4] 张亚中 于杰[4,5] 唐传华 YANG Zi-ying;WANG Fang-jing;JIN Chuan-shan;ZHANG Ya-zhong;YU Jie;TANG Chuanhua(Anhui University of Chinese Medicine,Hefei 230012;Anhui Innovative Team from Colleges for Scientific Research's Platform,Innovative Team in Researching Key Technologies Concerning Integration of Processing Chinese Medicine Decoction Pieces in Producing Area,Hefei 230012;Anhui Institute for Food ang Drug Control,Hefei 230051;Anhui Wansheng Traditional Chinese Medicine Decoction Pieces Co.,Ltd,Fuyang Anhui 236112;Anhui Research Center for Processing Engineering of Traditional Chinese Medicine Decoction Pieces,Fuyang Anhui 236112)

机构地区：[1]安徽中医药大学,合肥230012 [2]安徽省高校科研创新平台团队,中药饮片产地加工与炮制一体化关键技术研究创新团队,合肥230012 [3]安徽省食品药品检验研究院,合肥230051 [4]安徽省万生中药饮片有限公司,安徽阜阳236112 [5]安徽省中药饮片炮制加工工程研究中心,安徽阜阳236112

出　　处：《中南药学》2020年第3期449-453,共5页Central South Pharmacy

基　　金：安徽省重大科技专项(编号:17030801017)。

摘　　要：目的研究半夏及法半夏中有效成分的变化、毒性及镇咳祛痰作用,为法半夏的产业化生产提供实验依据,保证法半夏临床用药的安全性和有效性。方法通过测定草酸钙针晶的含量、急性毒性作用及致炎作用研究半夏和法半夏对小鼠毒性作用;通过测定总有机酸的含量、镇咳祛痰作用研究半夏和法半夏对小鼠药理作用。结果法半夏中草酸钙针晶含量显著降低,总有机酸含量无明显变化,急性毒性实验均未出现死亡现象,法半夏致炎作用显著低于半夏,其高、中剂量组镇咳祛痰药效较空白组仍为显著。结论该实验验证了法半夏炮制的"减毒-存效",同时为其产业化生产和临床用药的安全有效提供了科学依据。Objective To deteremine the changes in effective components, toxicity and relieving cough and expectorant effects of Pinellia ternata and Rhizoma Pinellinae Praeparata, provide experimental basis for the mass production of Rhizoma Pinellinae Praeparata, and ensure the safety and effectiveness of clinical safety of Rhizoma Pinelliae Praeparata. Methods The toxic effect of Pinellia ternata and Rhizoma Pinellinae Praeparata was measured by the content of calcium oxalate crystal, the acute toxicity and inflammation. The pharmacological action of Rhizoma Pinellinae Praeparata was verified by measuring the content of total organic acid, antitussive and expectorant effects. Results The content of calcium oxalate in Rhizoma Pinellinae Praeparata processed by the optimized processing technology was obviously reduced. The content of total organic acid had no significant change, and the acute toxicity experiment did not cause death. The inflammatory effect of Rhizoma Pinellinae Praeparata was significantly lower than that of Pinellia ternata, and its antitussive and expectorant effect was significant as compared with that of the blank group. Conclusion The experiment verifies the reducing toxicity and preserving efficacy in the processing of Rhizoma Pinellinae Praeparata, and provides scientific basis for its industrial production and clinical medication safety and effectiveness.

关 键 词：法半夏 半夏 草酸钙针晶 总有机酸 毒性作用 镇咳祛痰作用 

分 类 号：R283[医药卫生—中药学]