黑龙江省未治疗艾滋病患者耐药及病毒载量结果分析  

Analysis of drug resistance and viral load of untreated AIDS patients in Heilongjiang

作　　者：刘飞[1] 张锦慧 李婷[1] 张婕[1] 宋潇 李一[1] 刘铭曦 佟雪[1] LIU Fei;ZHANG Jin-hui;LI Ting;ZHANG Jie;SONG Xiao;LI Yi;LIU Ming-xi;TONG Xue(Heilongjiang Provincial Center for Disease Control and Prevention,Harbin,Heilongjiang 150030,China;Harbin Normal University)

机构地区：[1]黑龙江省疾病预防控制中心,黑龙江哈尔滨150030 [2]哈尔滨师范大学

出　　处：《中国公共卫生管理》2020年第1期125-127,共3页Chinese Journal of Public Health Management

基　　金：黑龙江省卫生计生委科研课题(2018-564)。

摘　　要：目的了解黑龙江省未治疗艾滋病病毒感染者(HIV)/艾滋病患者(AIDS)耐药情况,进行病毒载量结果相关性分析,为黑龙江省艾滋病精准防控提供依据。方法对黑龙江省132例未治疗HIV/AIDS进行基因型耐药及病毒载量检测,分析耐药突变位点及耐药发生情况以及病毒载量结果相关性。结果 132例未治疗的HIV/AIDS中,11例存在原发性耐药情况,占总检测数的8. 3%(11/132)。其中,非核苷类逆转录酶抑制剂(NNRTI)耐药率为36. 4%(4/11),核苷类逆转录酶抑制剂(NRTI)耐药率为18. 2%(2/11),蛋白酶类(PI)耐药率为45. 4%(5/11)。原发性耐药患者的病毒载量平均值为3. 04×10~5拷贝/m L(最高值为8. 65×10~5拷贝/m L,最低值为1. 41×10~2拷贝/m L),未发生原发性耐药患者的病毒载量平均值为4. 59×10~5拷贝/m L(最高值为1. 00×10~7拷贝/m L,最低值为1. 31×10~2拷贝/m L)。结论证据显示耐药毒株已经开始在黑龙江省进行传播。在开展抗病毒治疗前有必要进行治疗前耐药检测,同时应将艾滋病也有耐药毒株传播情况增加到艾滋病防治宣传内容中,进一步加强黑龙江省艾滋病防控工作力度。objective To investigate the characteristics of drug resistance in untreated HIV/AIDS patients in Heilongjiang and its correlation with viral load,provide evidence for accurate prevention and control of AIDS in Heilongjiang. Methods One hundred and thirty-two cases of untreated HIV/AIDS in Heilongjiang were tested for genotype resistance and viral load. Drug resistance mutation site and occurrence of drug resistance and correlation of viral load result was analyzed.Results Among 132 cases of untreated HIV/AIDS,11 cases had primary drug resistance,accounting for 8. 3%( 11/132)of the total detection number. Among them,the resistance of non-nucleoside reverse transcriptase inhibitors( NNRTI) was36. 4%( 4/11),the resistance of nucleoside reverse transcriptase inhibitors( NRTI) was 18. 2%( 2/11),and the resistance of protease was 45. 4%( 5/11). The mean viral load of patients with primary drug resistance was 3. 04 × 10~5 copies/ml( highest: 8. 65 × 10~5 copies/ml,lowest: 1. 41 × 10~2 copies/ml),and the mean viral load of patients without primary drug resistance was 4. 59 × 10~5 copies/ml( highest: 1. 00 × 10~7 copies/ml,lowest: 1. 31 × 10~2 copies/ml). Conclusion The evidence shows that the resistant strain has started to spread in Heilongjiang province. Therefore,it is necessary to carry out drug resistance testing before antiviral treatment. Meanwhile,the transmission of drug-resistant strains of AIDS should be added to the AIDS prevention and control propaganda,so as to further strengthen the AIDS prevention and control work in Heilongjiang province.

关 键 词：艾滋病病毒感染者/艾滋病患者 原发性耐药 病毒载量 未治疗 

分 类 号：R512.91[医药卫生—内科学]