肺动脉高压中医证候与预后指标的相关性  

Clinical research on TCM syndrome characteristics of pulmonary hypertension and correlation with prognostic indexes

作　　者：王蓓蕾[1,2] 阮越勇 于洋[2] 张纾难[1,2] WANG Bei-lei;RUAN Yue-yong;YU Yang;ZHANG Shu-nan(Beijing University of Chinese Medicine,Beijing 100029,China;Department of TCM Pulmonary Diseases,Center of Respiratory Medicine,China-Japan Friendship Hospital,National Clinical Research Center for Respiratory Diseases,Beijing 100029,China)

机构地区：[1]北京中医药大学,北京100029 [2]中日友好医院中医肺病科,中日友好医院呼吸中心,国家呼吸疾病临床研究中心,北京100029

出　　处：《中华中医药杂志》2020年第2期604-607,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81804044);国家临床重点专科。

摘　　要：目的:探讨肺动脉高压中医证候与预后指标的相关性。方法:采用横断面研究方法,收集32例肺动脉高压患者四诊信息,总结其中医证候特点及与预后指标NT-proBNP、六分钟步行距离、心功能分级的相关性。结果:病性证素以气虚、血瘀、水饮为主。病位证素以肺、脾、肾、心为主。证型分布:肺动脉高压基本证型是气虚血瘀证,其次是阳虚血瘀水泛证、阴虚血瘀水停证、气阴两虚兼血瘀证。水饮证与NT-proBNP呈正相关,与六分钟步行距离呈负相关。阴虚血瘀水停证NT-proBNP水平最高,六分钟步行距离最短。结论:气虚血瘀证为肺动脉高压主要证型,水饮证与预后指标密切相关。Objective:To explore the correlation between TCM syndrome and prognostic indexes of pulmonary hypertension.Methods:The cross-sectional study method was adopted to collect the four-diagnosis information of 32 patients with pulmonary hypertension and to summarize the characteristics of its TCM syndromes and the correlation with prognostic indexes of NT-proBNP levels,six minutes walk distance and cardiac function classification.Results:Qi deficiency,blood stasis and water-rheum are the main pathogenic syndromes.Lung,spleen,kidney,and heart are the main syndrome elements.Distribution of syndromes:the basic syndromes of pulmonary hypertension was qi deficiency and blood stasis syndrome,followed by yang deficiency and blood stasis with fluid retention syndrome,yin deficiency and blood stasis with fluid retention syndrome,qi and yin deficiency with blood stasis syndrome.Fluid retention syndrome was positively correlated with NT-proBNP levels and negatively correlated with the 6-minute walking test.NT-proBNP levels of yin deficiency and blood stasis with fluid retention syndrome were the highest whereas the 6-minute walking test was the shortest.Conclusion:Qi deficiency and blood stasis syndrome are the main types of pulmonary hypertension.Water-rheum syndrome is closely related to prognosis indicators.

关 键 词：肺动脉高压 动脉性肺动脉高压 慢性血栓栓塞性肺动脉高压 中医证候 预后指标 氨基末端脑钠肽前体 六分钟步行距离 心功能分级 

分 类 号：R259[医药卫生—中西医结合]