肺结核患者密切接触者对6个月单用异烟肼预防性治疗方案的接受度  

Acceptability of 6-month prophylactic isoniazid therapy in latently infected close contacts of tuberculosis patients

作　　者：祖筱雯 要玉霞[2] 龚德华 汪清雅 任哲雯 成君[1] 张灿有[1] 夏愔愔[1] 陈卉[1] 徐彩红[1] 张慧[1] ZU Xiao-wen;YAO Yu-xia;GONG De-hua(National Center for Tuberculosis Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China;不详)

机构地区：[1]中国疾病预防控制中心结核病预防控制中心,北京102206 [2]河南省疾病预防控制中心 [3]湖南省胸科医院 [4]重庆市结核病防治所

出　　处：《中国公共卫生》2020年第3期369-374,共6页Chinese Journal of Public Health

基　　金：“十三五”国家科技重大专项(2017ZX10201302);中国疾病预防控制中心科研项目(JY18-2-18);重庆市科卫联合医学科研项目(2018MSXM026)。

摘　　要：目的了解结核潜伏感染的肺结核患者密切接触者对6个月单用异烟肼预防性治疗方案的接受程度及其影响因素。方法2018年1月-2019年11月在全国17个县区内,结核病定点医疗机构选取了991名潜伏感染的肺结核患者密切接触者,通过问卷调查和相关检查,了解其对6个月单用异烟肼预防性治疗方案的接受情况及其影响因素。结果在991名符合预防性治疗标准的密切接触者中,有633名(63.9%)接受并进行了6个月单用异烟肼预防性治疗。其中男性(OR=1.39,P<0.05)、学生(OR=2.26,P<0.05)、收入中等(OR=1.54,P<0.05)的指示病例所对应的密切接触者治疗接受度较高。结论结核潜伏感染的密切接触者对6个月单用异烟肼预防性治疗方案的接受度主要受其指示病例特征的影响。Objective To examine the acceptance of 6-month isoniazid prophylactic therapy(IPT)and its impact factors in latently infected close contacts of tuberculosis(TB)patients.Methods We recruited 991 latently infected close contacts(aged averagely aged 39 years,61.8%females)of TB patients at designated TB treatment clinics in 17 counties/districts of 3 provincial-level regions in China 3 and carried out a 6-month IPT in the contacts from January 2018 to November 2019.Questionnaire interviews and laboratory tests were performed in the contacts to collect information on the acceptance and correlates of the IPT.Results Of all the participants,633(63.9%)received the 6-month IPT.The results of univariate logistic analysis demonstrated that compared to the those contacting with the TB patients being female,being other occupation groups,and having high or low average family annual income per capita,the participants contacting with the TB patients being male(odds ratio[OR]=1.38),being student(R=2.26),and with a middle income(OR=1.54)were more likely to receive IPT significantly(P<0.05 for all).Conclusion The acceptability of 6-month prophylactic isoniazid therapy among latently infected close contacts of tuberculosis patients is mainly influenced by gender,occupation and family average annual income of the patients the contacts being exposed to.

关 键 词：密切接触者 结核潜伏感染 预防性治疗 接受度 

分 类 号：R521[医药卫生—内科学]