皮肤干细胞治疗的发展历程  

The journey toward skin stem cell therapy

作　　者：廖新化 LIAO Xinhua(School of Life Sciences,Shanghai University,Shanghai 200444,China)

机构地区：[1]上海大学生命科学学院,上海200444

出　　处：《自然杂志》2020年第2期91-95,共5页Chinese Journal of Nature

基　　金：国家自然科学基金面上项目(81972563)。

摘　　要：大疱性表皮松解症病人通过用干细胞全身换皮已经实现了根治。从不治之症到可以治疗,皮肤干细胞疗法走过了漫长的发展历程。从不经意间发明皮肤干细胞体外培养的技术,到利用皮肤干细胞在体内再生皮肤组织,再到治疗深度烧伤和角膜灼伤,最后到治疗遗传性皮肤病,这个临床医学上的突破是干细胞治疗和基因治疗结合的典范。文章将回顾这一发展历程,展示科学发展的规律,为基因治疗和干细胞治疗在其他领域的发展提供思路。Patients with epidermolysis bullosa were able to be cured through replacing the entire skin with stem cells.From incurable to curable disease,there is a long and winding road leading to the birth of skin stem cell therapy.It started from the technique unintentionally invented for culturing skin stem cells in vitro.Later on,scientists regenerated skin tissue in vivo using cultured stem cells,and successfully treated patients with deep burn on skin or chemical burn on cornea.At last,this technique was successfully used to cure skin genetic disease.This clinical breakthrough is a milestone for stem cell and gene therapies.Reviewing this journey,exhibiting the process of how these discoveries occurred,would provide a model and reference for gene and stem cell therapies in other fields.

关 键 词：基因治疗 干细胞治疗 皮肤干细胞 大疱性表皮松解症 

分 类 号：R751.05[医药卫生—皮肤病学与性病学]