基于PubMed数据库的幽门螺杆菌耐药状况的文献计量学分析  

Bibliometric analysis of drug resistance state in Helicobacter pylori based on PubMed

作　　者：潘信义[1] 韦碧柳[1] Pan Xinyi;Wei Biliu(Liuzhou People’s Hospital,Liuzhou 545006,Guangxi,China)

机构地区：[1]广西柳州市人民医院,广西柳州545006

出　　处：《右江民族医学院学报》2020年第2期228-232,共5页Journal of Youjiang Medical University for Nationalities

摘　　要：目的分析PubMed数据库里国际上研究幽门螺杆菌耐药文献的分布特点和研究现状,为耐药幽门螺杆菌防治提供参考信息。方法检索PubMed数据库中收录的国际上有关幽门螺杆菌耐药情况的文献,运用书目共现分析系统(BICOMB 2.0)、CytoScape3.6.1及SPSS 22软件对高频主题词进行共现分析及聚类分析。结果共检索出幽门螺杆菌耐药情况的相关文献154篇,年发文量首先呈波动性上升趋势,随后有所放缓,语种以英文为主。发文量以亚洲国家和地区为主。该领域涉及最多的主题词和副主题词前5名为Helicobacter pylori/drug effects,Helicobacter Infections/drug therapy,Anti-Bacterial Agents/pharmacology,Bacterial Drug Resistance和Helicobacter pylori/genetics,说明这几个方面是目前研究者关注的热点及共同点。结论幽门螺杆菌根除方案取决于患者的地理位置和既往治疗史,通过对其耐药情况进行文献计量学分析,可了解不同地区不断更新的幽门螺杆菌流行病学及耐药数据,亦可以知晓该领域的主要研究方向及其发展现状,最终为幽门螺杆菌耐药防治提供参考。Objective In order to provide references for prevention and treatment of drug-resistant Helicobacter pylori,the distribution features and research status of international literatures related to drug resistance in Helicobacter pylori were analyzed based on PubMed.Methods The international literatures related to drug resistance in Helicobacter pylori were retrieved from the PubMed database.Co-occurrence analysis and cluster analysis of the high-frequency subject headings were conducted by using bibliographic item co-occurrence matrix builder 2.0(BICOMB 2.0)software,CytoScape3.6.1 drawing software and SPSS 22 statistical analysis software.Results A total of 154 literatures related to drug resistance in Helicobacter pylori were collected.The amount of annual published articles firstly showed wavy increase trend,then slightly slowed down.The major language of literatures was English.The most papers were from Asian countries and regions.The top 5 of the high-frequency subject headings and the subheadings involved in this study were Helicobacter pylori/drug effects,Helicobacter Infections/drug therapy,Anti-Bacterial Agents/pharmacology,Bacterial Drug Resistance and Helicobacter pylori/genetics.The results showed that those aspects were the hotspots and common points of current researchers.Conclusion The Helicobacter pylori eradication program depends on the patient’s geographic location and previous treatment history.By conducting a bibliometric analysis of the drug resistance,you can understand the epidemiological and drug resistance data of Helicobacter pylori that is constantly updated in different regions,and also understand the main research directions and development status in this field,which will eventually provide a reference for the prevention and treatment of drug resistance in Helicobacter pylori.

关 键 词：PUBMED 幽门螺杆菌 耐药 文献计量学 聚类分析 

分 类 号：R377[医药卫生—病原生物学]