我国台湾地区H5亚型禽流感病毒遗传进化分析  被引量:1

Phylogenetic Analysis on H5 Subtype Avian Influenza Virus in Taiwan of China

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作  者:蒋文明[1] 刘朔[1] 宋建德[1] 彭程[1] 孙映雪[1] 于晓慧 李阳 王静静[1] 刘华雷[1] Jiang Wenming;Liu Shuo;Song Jiande;Peng Cheng;Sun Yingxue;Yu Xiaohui;Li Yang;Wang Jingjing;Liu Hualei(China Animal Health and Epidemiology Center,Qingdao,Shandong 266032,China)

机构地区:[1]中国动物卫生与流行病学中心,山东青岛266032

出  处:《中国动物检疫》2020年第5期33-36,74,共5页China Animal Health Inspection

基  金:国家重点研发计划项目(2017YFC1200503)。

摘  要:2019年以来,我国台湾地区多次暴发H5亚型禽流感疫情,病原包括H5N2、H5N5、H7N7等亚型禽流感病毒。为了解台湾地区流行的H5亚型禽流感病毒的分子流行特点,下载GenBank Influenza Virus Database和GISAID中公布的台湾地区所有H5亚型禽流感病毒HA序列,对近年来公开报道的台湾地区流行的H5亚型禽流感病毒进行遗传进化分析,并与大陆地区流行的H5亚型禽流感病毒进行比较。结果显示:台湾地区同时存在欧亚谱系和美洲谱系两个分支的H5亚型禽流感病毒流行,而大陆地区流行的H5亚型病毒都是欧亚谱系。欧亚谱系中,台湾地区流行的主要是第2.3.4.4a分支病毒,而大陆地区流行的主要是2.3.4.4d分支病毒,两个地区流行的H5病毒谱系并不完全一致。由于台湾地区的禽流感生态系统与大陆地区南方相似,因此台湾地区流行的美洲谱系H5亚型禽流感病毒有通过野鸟传播传入大陆地区的潜在风险,应提高警惕,加强禽流感调查监测,严厉查处非法走私禽类及其产品的活动。本研究为我国H5亚型禽流感防控提供了信息支持。H5 subtype avian influenza(AI)including H5 N2,H5 N5 and H7 N7 had taken place several times in Taiwan of China since 2019. In order to identify the molecular characteristics of H5 subtype AIV prevalent in Taiwan,all HA sequences of the viruses isolated from Taiwan registered in GenBank Influenza Virus Resource and GISAID Database were downloaded to analyze their evolutionary relationships,and these H5 subtype AIV strains were compared with those prevalent in China's Mainland. The results showed that the H5 subtype AIV prevalent in Taiwan belonged to Eurasian or American lineage,while the strains prevalent in China's Mainland only fell into Eurasian lineage. For Eurasian lineage,clade 2.3.4.4 a virus was mainly prevalent in Taiwan,while clade 2.3.4.4 d virus was prevalent in China's Mainland. As avian influenza ecosystem in Taiwan was similar to that in southern China's Mainland,the viruses of American lineage prevalent in Taiwan had a potential risk of being introduced into China's Mainland via wild birds,so it was necessary to improve early warning system,strengthen investigation and surveillance on AIV,investigate and handle with any illegal smuggling of poultry and related products. In conclusion,some data was provided to prevent and control H5 subtype AI in China.

关 键 词:禽流感 H5亚型 台湾 遗传进化分析 

分 类 号:S852.65[农业科学—基础兽医学]

 

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