副结核病诊断和防控研究进展  

Research Progress on the Diagnosis and Control of Paratuberculosis

作　　者：郭永丽 张君 孙刚 高明春[2] Guo Yongli;Zhang Jun;Sun Gang;Gao Mingchun(Heilongjiang Center for Animal Disease Prevention and Control,Harbin,Heilongjiang 150030,China;Northeast Agricultural University,Harbin,Heilongjiang 150030,China)

机构地区：[1]黑龙江省疾病预防与控制中心,黑龙江哈尔滨150030 [2]东北农业大学,黑龙江哈尔滨150030

出　　处：《中国动物检疫》2020年第5期80-86,共7页China Animal Health Inspection

基　　金：国家奶牛产业技术体系建设项目(CARS-36)。

摘　　要：副结核病是世界范围流行的以危害反刍动物为主的动物疫病,严重威胁畜牧业发展和人类公共卫生安全,我国将其列为二类动物疫病。由于该病病原感染机体的免疫反应复杂,需要根据不同感染时期施以不同的诊断方法;目前对于该病没有理想的疫苗可用,现有疫苗对预防感染无效;需要根据不同目标采取不同防控策略,国际通用策略为"大缸奶质量保证措施"(BMPAQ)和"密集副结核程序"(IPP)。未来需要研究更加方便、高效、快捷的诊断方法,加快新型疫苗研发、减少疫苗副作用及检测干扰,进一步强化多部门联动及防控宣传。Paratuberculosis is a worldwide animal disease,mainly endangering ruminants and threatening the development of animal husbandry and the safety of human public health,and is listed as class II animal diseases in China. In view of the complex immune responses of the infected organisms,appropriate diagnostic methods should be applied in different infection periods;at present,no any corresponding effective vaccines are available;different prevention and control strategies should be taken for different objectives,and the"Bulk Tank Milk Quality Assurance Programme"(BMPAQ)and"Intensive Paratuberculosis Programme"(IPP)have been commonly applied internationally. In addition,some suggestions were put forward in this paper,including developing more convenient,efficient and rapid methods,quickening the development of new vaccines,reducing the side-effect of vaccines and detection interference,and strengthening cooperation among various departments and publicity of prevention and control of the disease.

关 键 词：副结核病 流行现状 诊断 疫苗 防控策略 

分 类 号：S851.3[农业科学—预防兽医学]