单中心双瓣置换应用Del-Nido停搏液与冷血停搏液心肌保护效果  

Myocardial Protective Effect of Del Nido Cardioplegia and Cold Blood Cardioplegia in Single Center Double Valve Replacement

作　　者：张中伟[1] ZHANG Zhong-wei(Dept.of Cardiovascular Surgery,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China)

机构地区：[1]昆明医科大学第一附属医院心脏大血管外科,云南昆明650032

出　　处：《昆明医科大学学报》2020年第4期79-81,共3页Journal of Kunming Medical University

基　　金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2017FE468(-194)]。

摘　　要：目的回顾性分析昆明医科大学第一附属医院心脏大血管外科双瓣置换术中应用Del-Nido停搏液与冷血停搏液的心肌保护效果。方法选取2018年5月至2019年3月昆明医科大学第一附属医院心脏大血管外科心脏大血管外科132例双瓣置换手术患者,对比术中心脏自动复跳率、停机10 min平均动脉压(MAP)、停机10min中心静脉压(CVP)、术后使用多巴胺天数。132例患者分为AB两组,其中70例患者应用冷血停搏液,作为A组(男32例,女38例),62例患者应用Del-Nido停搏液作为B组(男26例,女36例)。结果 A组患者12例自动复跳,复跳率17.1%;B组患者有20例自动复跳,复跳率32.2%,差异有统计学意义(P<0.05)。MAP(mm Hg):A组:(81.6±5.4),B组:(83.2±6.6),P=0.12;CVP (mm Hg):A组:(9.9±1.2),B组:(10.1±1.2),P=0.19;术后使用多巴胺(d):A组:(4.7±1.0),B组:(4.4±1.1),P=0.11。两组患者在停机10 min平均动脉压(MAP)、停机10 min中心静脉压(CVP)、术后使用多巴胺天数无明显差异。心脏自动复跳率差异有统计学意义(P <0.05)。结论双瓣置换术中使用Del-Nido停搏液可以提高心脏自动复跳率。Objective To retrospectively analyze the myocardial protective effect of del Nido cardioplegia and cold blood cardioplegia in double valve replacement of cardiovascular surgery in the First Affiliated Hospital of Kunming Medical University. Me thods From May 2018 to March 2019, 132 patients with double valve replacement inthe cardiovascular surgery of our hospital were selected to compare the rate of automatic cardiac rebound, mean arterial pressure(map) in 10 minutes of shutdown, central venous pressure(CVP) in 10 minutes of shutdown and the days of dopamine use after operation. These 132 patients were divided into two groups:group A(32 males, 38 females) and group B(26 males, 36 females). Re s ults 12 patients in group A had automatic rebound, and the rate of rebound was 17.1%;20 patients in group B had automatic rebound, and the rate of rebound was 32.2%, P = 0.04. The difference was statistically significant. Map(mm Hg) : group A:(81.6± 5.4), group B:(83.2 ± 6.6), P = 0.12;CVP(mm Hg) : group A:(9.9 ± 1.2), group B:(10.1 ±1.2),P = 0.19;postoperative dopamine use(day) : group A:(4.7 ± 1.0), group B:(4.4 ± 1.1), P = 0.11.There was no significant difference between the two groups in the mean arterial pressure(map), central venous pressure(CVP) and postoperative days of dopamine use. There was significant difference in the rate of cardiac automatic rebound(P < 0.05). Conclus ion The use of del Nido cardioplegia in double valve replacement can improve the rate of cardiac automatic rebound.

关 键 词：Del-Nido 冷血停搏液 心肌保护 

分 类 号：R541[医药卫生—心血管疾病]