中老年男性T2DM患者腹部脂肪分布与骨代谢指标及骨密度的相关性  

Correlation of Abdominal Fat Distribution with Bone Metabolic Markers and Bone Mineral Density in Middle-aged and Elderly Male Patients with T2DM

作　　者：熊慧勤 栗夏莲[1] XIONG Hui-qin;LI Xia-lian(Department of Endocrinology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院内分泌科,河南郑州450052

出　　处：《河南医学研究》2020年第13期2334-2337,共4页Henan Medical Research

摘　　要：目的探讨中老年男性2型糖尿病(T2DM)患者腹部脂肪分布与骨代谢指标及骨密度的相关性。方法收集2018年8月至2019年10月在郑州大学第一附属医院内分泌科住院的195例中老年男性T2DM患者的临床资料,采用定量CT测量内脏脂肪(VAT)、皮下脂肪(SAT)面积及腰椎骨密度,根据VAT值以3分位数法分为3组:T1组(VAT<184.1 cm 2)、T2组(VAT≥184.1 cm 2且<243.4 cm 2)、T3组(VAT≥243.3 cm 2)。比较3组一般资料、骨代谢指标及骨密度情况,分析腹部脂肪与各临床指标的相关性。结果T1组糖化血红蛋白(HbA1c)、Ⅰ型前胶原氨基末端肽(PⅠNP)、骨钙素(BGP)、骨密度均高于T2组和T3组,差异有统计学意义(均P<0.05)。T2组和T3组体质量指数(BMI)均高于T1组,T3组BMI高于T2组,差异有统计学意义(均P<0.05)。T3组年龄大于T1组,差异有统计学意义(P<0.05)。VAT、SAT均与BMI呈正相关,与PⅠNP、BGP呈负相关(均P<0.05)。VAT与年龄呈正相关,与骨密度呈负相关(均P<0.05)。年龄和VAT均与骨密度呈负相关(均P<0.05)。结论年龄和腹部内脏脂肪可能是影响中老年男性T2DM患者骨密度的危险因素。Objective To explore the correlation of abdominal fat distribution with bone metabolic markers and bone mineral density in middle-aged and elderly male patients with type 2 diabetes mellitus(T2DM).Methods The clinical data of 195 middle-aged and elderly male patients with T2DM in the Department of Endocrinology,the First Affiliated Hospital of Zhengzhou University were collected from August 2018 to October 2019.All patients received quantitative computed tomography to measure the visceral adipose tissue(VAT)area,subcutaneous adipose tissue(SAT)area and bone mineral density of lumbar vertebrae.They were divided into three groups depending on the value of VAT:T1 group(VAT<184.1 cm 2),T2 group(VAT≥184.1 cm 2 and<243.4 cm 2)and T3 group(VAT≥243.3 cm 2).The common data,bone metabolic markers and bone mineral density in three groups were compared.The correlations between abdominal fat and clinical indexes were analyzed.Results The glycosylated hemoglobin(HbA1c),typeⅠprocollagen amino-terminal peptide(PⅠNP),bone glaprotein(BGP)and bone mineral density in T1 group were higher than those in T2 group and T3 group,and the differences were statistically significant(all P<0.05).The body mass index(BMI)in T2 group and T3 group were higher than that in T1 group,and the BMI in T3 group was higher than that in T2 group,and the differences were statistically significant(all P<0.05).The age in T3 group was older than that in T1 group,and the difference was statistically significant(P<0.05).VAT and SAT were both positively correlated with BMI,and VAT and SAT were negatively correlated with PⅠNP and BGP(all P<0.05).VAT was positively correlated with age(P<0.05).VAT was negatively correlated with bone mineral density(P<0.05).Age and VAT were both negatively correlated with bone mineral density(both P<0.05).Conclusion Age and abdominal VAT may be risk factors for bone mineral density in middle-aged and elderly male patients with T2DM.

关 键 词：中老年男性 2型糖尿病 骨密度 骨代谢指标 腹部脂肪 

分 类 号：R587.1[医药卫生—内分泌]