调节性免疫细胞在异种移植免疫中的作用  

The function of regulatory immunological cell in xenotransplantation immunity

作　　者：石炳毅 陈文 刘志佳 Shi Bingyi;Chen Wen;Liu ZhijiaOrgan(Transplantation Institute of the 8th Medical Center of Chinese People s Liberation Army General Hospital,Beijing 100091,China)

机构地区：[1]中国人民解放军总医院第八医学中心全军器官移植研究所,北京100091

出　　处：《器官移植》2020年第3期321-325,共5页Organ Transplantation

基　　金：国家自然科学基金(81570680,81571555)。

摘　　要：异种移植是未来解决器官短缺最有前景的方法。近年来基因编辑和免疫学技术的进步推动了异种移植的快速发展,但是异种移植的临床应用仍然存在诸多难以克服的障碍,其中排斥反应是引起异种移植失败的最重要原因。调节性免疫细胞是机体内一群具有负性调节功能的免疫细胞,能够抑制同种异体移植排斥反应,延长移植物的存活时间。本文总结了近几年调节性免疫细胞在异种移植应用的研究进展,为异种移植排斥反应预防和治疗提供参考。Xenotransplantation is the most promising method to resolve the organ shortage problem in the future.In recent years,the advances in gene editing and immunological technique have driven the rapid development of xenotransplantation.However,there are still many insurmountable obstacles in the clinical application of xenotransplantation,among which the rejection is the most important cause of the xenotransplantation failure.Regulatory immunological cells are a group of immunological cells with the negative regulation function in the body,which can inhibit allotransplantation rejection and prolong the survival time of the graft.This paper summarized the research progress of regulatory immunological cells in the xenotransplantation application in recent years,providing reference for the prevention and treatment of xenotransplantation rejection.

关 键 词：调节性免疫细胞 异种移植 排斥反应 移植免疫 调节性T细胞(Treg) 调节性树突状细胞(DCreg) 滤泡调节性T细胞(Tfr) 调节性B细胞(Breg) 

分 类 号：R617[医药卫生—外科学] R392.4[医药卫生—临床医学]