老年人口服常用剂量缓释茶碱不良反应与血药浓度分析  

Oral Conventional Dose Sustained-release Theophylline in Elderly Patients:Adverse Reactions and Serum Drug Levels

作　　者：姬路鹏 常瑞明[2] 许倩琼 陈兢兢[3] 陆少范 陈华新 吕诗敏 梁庭都 JI Lu?peng;CHANG Rui?ming;XU Qian?qiong;CHEN Jing?jing;LU Shao?fan;CHEN Hua?xin;LV Shi?min;LIANG Tingdu(Department of Medicine,The Fifth People’s Hospital of Zhuhai,519055;Boji Medical Center,Sun Yat?sen Memorial Hospital,Sun Yat?sen University;Department of Respiratory Diseases,Guangdong General Hospital;Department of Radiology,The Fifth People’s Hospital of Zhuhai)

机构地区：[1]广东省珠海市第五人民医院内科,519055 [2]中山大学孙逸仙纪念医院博济医疗中心 [3]广东省人民医院呼吸科 [4]广东省珠海市第五人民医院放射科

出　　处：《岭南急诊医学杂志》2020年第1期64-66,共3页Lingnan Journal of Emergency Medicine

基　　金：广东省珠海市卫计局医学科研基金(2016-25)。

摘　　要：目的:分析老年人短时间内(1周)口服常用剂量缓释茶碱的不良反应发生情况及血药浓度监测结果,为临床合理用药提供依据。方法:回顾性分析2012年1月至2018年12月口服常规剂量缓释茶碱且采用荧光偏振免疫法检测茶碱血药浓度的老年住院患者临床资料,并收集不良反应发生情况。结果:共纳入352例,其中男性290例,女性62例,平均年龄(80.53±8.46)岁,其中血清茶碱浓度水平范围为0.7 mg/L-19.72 mg/L,平均水平为(8.03±3.88)mg/L,小于6 mg/L112例(31.82%),6-15 mg/L有199例(56.53%),大于15 mg/L有41例(11.65%,无血药浓度水平超过20 mg/L者),大多数患者无茶碱不良反应表现,部分病人可出现不同程度的消化、循环、神经系统表现,无严重茶碱中毒反应。结论:老年人短时间(1周内)口服常用剂量缓释茶碱的不良反应轻微,对短期口用茶碱缓释片者,如无茶碱中毒表现,可无须监测血药浓度。Objective:To analyze the adverse events and the serum theophylline levels in the elderly patients treated with sustained?release theophylline in a week.Methods:The serum concentration of the prescription dose of sustained?release theophylline was measured by fluorescence polarization immunoassay from January 2012 to December 2018,and the incidence of adverse reactions was recorded.Results:A total of 352 patients were included in 290 males and62femaleswithanaverageageof(80.53±8.46)years.Theconcentration of serum theophylline was 0.7mg/L-19.72mg/L,with an average of(8.03±3.88)mg/L,There were 112 cases(31.82%)with less than 6 mg/L,199 cases(56.53%)in 6-15 mg/L,41 cases(11.65%,no blood concentration exceeding 20 mg/L),and most patients without theophylline adverse reactions,some patients may be varying degrees of digestion,circulation,nervous system performance,no serious theophylline poisoning reaction.Conclusion:The adverse reactions of the elderly patients who were treated with sustained?release theophylline in a week was mild,if there was no theophylline poisoning performance,blood concentration monitoring was not necessary.

关 键 词：茶碱 血药浓度监测 老年人 

分 类 号：R969[医药卫生—药理学]