2019-新型冠状病毒感染的肺炎患者血清白蛋白浓度与淋巴细胞水平关系的临床研究  

The clinical study on the relationship between serum albumin concentration and lymphocyte levels in patients with 2019-novel coronavirus pneumonia

作　　者：李若青 田继刚[2] 杨芳[2] 余杰 吕雷 孙光炎 王洪群 刘颖宏 陈曦[3] 方清永 杨晓娟 Li Ruoqing;Tian Jigang;Yang Fang;Yu Jie;Lv Lei;Sun Guangyan;Wang Hongqun;Liu Yinghong;Chen Xi;Fang Qingyong;Yang Xiaojuan(Department of General Medicine,Chongqing University Central Hospital,Chongqing Emergency Medical Center,Chongqing 400014,China;Department of Infectious Diseases,Hanchuan City Peopled Hospital,Hanchuan 431600,Xiaogan City,Hubei Province,China;Department of Respiratory Medcine,Chongqing University Central Hospital,Chongqing Emergency Medical Center,Chongqing 400014,China;Department of Hospital Infection Management,Chongqing University Central Hospital,Chongqing Emergency Medical Center,Chongqing 400014,China)

机构地区：[1]重庆大学附属中心医院/重庆市急救医疗中心全科医学科,重庆市400014 [2]汉川市人民医院感染科,湖北省孝感市431600 [3]重庆大学附属中心医院/重庆市急救医疗中心呼吸内科,重庆400014 [4]重庆大学附属中心医院/重庆市急救医疗中心医院感染管理科,重庆400014

出　　处：《中华急诊医学杂志》2020年第4期478-482,共5页Chinese Journal of Emergency Medicine

摘　　要：目的探讨2019-新型冠状病毒(2019-nCoV)感染的肺炎(COVID-19)患者不同血清白蛋白浓度与淋巴细胞水平之间的关系。方法采用回顾性研究方法,收集2020年1月24日至2月12日在湖北省孝感市汉川市人民医院欢乐街院区住院的205例COVID-19患者的一般资料、血清白蛋白(ALB)、淋巴细胞数(LYM)、淋巴细胞百分比(LYM%)及其他检验参数水平,分析COVID-19患者的临床资料特征;以ALB浓度35 g/L为切点分为低ALB组和正常ALB组,行组间对照分析不同ALB浓度时LYM、LYM%水平的差异和LYM、LYM%下降的发生率差异;分析低白蛋白血症时ALB浓度与LYM、LYM%水平的相关性。结果17.5%的COVID-19患者合并低白蛋白血症,低ALB组的LYM、LYM%水平显著低于正常ALB组(P<0.001),低ALB组的LYM、LYM%下降的发生率显著高于正常ALB组(P<0.05),低ALB组中LYM、LYM水平分别与血清ALB浓度呈显著正相关(P<0.05)。结论COVID-19患者淋巴细胞水平下降可能与低白蛋白血症有关,应积极干预COVID-19合并低白蛋白血症的患者,维持血清白蛋白在正常范围。ObjectiveTo explore the relationship between different serum albumin and lymphocyte levels in patients with 2019-novel coronavirus(2019-nCoV)pneumonia(COVID-19).MethodsA retrospective study was performed to identify the characteristics of the clinical data of 205 COVID-19 patients who were hospitalized in the Happy Street of Hanchuan People's Hospital,Xiaogan,Hubei Province from January 24 to February 12,2020,including their general information,serum albumin(ALB)levels,lymphocyte counts(LYM),percentage of lymphocytes(LYM%)and other laboratory parameter levels.Low ALB group and normal ALB group were demarcated by the concentration of 35 g/L,further to identify the differences of LYM and LYM%levels and the incidence of LYM and LYM%decline at different ALB levels between groups,as well as the correlation between ALB and LYM,LYM%levels in hypoalbuminemia conditions.Results17.5%of COVID-19 patients were associated with hypoalbuminemia.The levels of LYM and LYM%in the low ALB group were significantly lower than those in the normal ALB group(P<0.001).The incidence of LYM and LYM%decline in the low ALB group was significantly higher than those in the normal ALB group(P<0.001).The levels of LYM and LYM%in the low ALB group were significantly positively correlated with serum ALB concentrations(P<0.05).ConclusionsThe decrease of lymphocyte levels in COVID-19 patients may be correlated to hypoalbuminemia.COVID-19 patients complicated by hypoalbuminemia should be actively intervened to maintain serum albumin in the normal range.

关 键 词：新型冠状病毒 新型冠状病毒肺炎 白蛋白类 低白蛋白血症 感染性疾病 淋巴细胞计数 炎症因子 治疗 综合 

分 类 号：R563[医药卫生—呼吸系统]