胰岛体内成像技术的进展  

Advances of in vivo imaging technology of pancreatic islets

作　　者：陈逗逗 刘坤钰 郑旭琴[1] CHEN Doudou;LIU Kunyu;ZHENG Xuqin(Department of Endocrinology,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China)

机构地区：[1]南京医科大学第一附属医院内分泌科,江苏南京210029

出　　处：《徐州医科大学学报》2020年第4期309-312,共4页Journal of Xuzhou Medical University

基　　金：江苏省科技厅课题(BE2018748)。

摘　　要：糖尿病的主要发病机制包括胰岛素抵抗和胰岛B细胞功能障碍。动物实验中可以通过胰腺组织切片计算B细胞数和胰岛素分泌量评估胰岛B细胞功能损伤或恢复程度。临床试验中无法使用有创性方法获取胰腺组织切片,因此如何开发无创性成像技术精确评估体内胰岛B功能成为了研究的热点。本文将多种追踪胰岛B细胞成像的技术进行了汇总。The main pathogenesis of diabetes includes insulin resistance andβcell dysfunction.In animal experiments,the number ofβ-cells and the amount of insulin secretion can be calculated from pancreatic tissue sections to evaluate the degree of functional damage or recovery ofβ-cells.In clinical trials,it is impossible to use invasive methods to obtain pancreatic tissue sections,so how to develop non-invasive imaging technology to accurately evaluate theβ-cell function of islets in vivo has become a research hot spot.In this paper,a variety of techniques for tracking isletβ-cell imaging are summarized.

关 键 词：糖尿病 胰岛细胞增殖 胰岛细胞移植 胰岛B细胞成像 

分 类 号：R587.1[医药卫生—内分泌]