六种苯并咪唑化合物的NMR分析  

NMR Analysis of Six Benzimidazole Derivatives

作　　者：赵春欣 宗春蕾[2] 高翔[1] 郭娟[1] 孙伟[1] ZHAO Chun-xin;ZONG Chun-lei;GAO Xiang;GUO Juan;SUN Wei(Key Laboratory of Synthetic and Natural Functional Molecular Chemistry,Ministry of Education,College of Chemistry&Material Science,Northwest University,Shaanxi Xi'an 710127;State Key Laboratory of Continental Dynamics,Department of Geology,Northwest University,Shaanxi Xi'an 710029,China)

机构地区：[1]合成与天然功能分子化学教育部重点实验室,西北大学化学与材料科学学院,陕西西安710127 [2]大陆动力学国家重点实验室,西北大学地质学系,陕西西安710029

出　　处：《广州化工》2020年第8期74-76,123,共4页GuangZhou Chemical Industry

基　　金：国家自然科学基金(21672169);西安市有机分子工程重点实验室项目(201805058ZD9CG42)。

摘　　要：苯并咪唑化合物是苯环与咪唑环相连构成的具有生物活性的化合物,含这类结构的化合物具有杀菌、杀虫等作用,广泛应用于医药化工产品中。其结构中质子数量少且化学环境相似,核磁共振(NMR)氢谱芳香区易出现谱峰重叠,不利于质子化学位移指认。13C核性质较稳定,测量精度较高,谱图化学位移值范围较大,不易发生谱峰重叠。本文通过1H NMR、13C NMR、ROESY、HSQC、HMBC对谱峰重叠严重质子的化学位移进行区分,准确归属1H、13C核的化学位移。Benzimidazole derivative is a class of highly biological active compounds which build with the linkage of benzene ring and imidazole ring. This kind of compounds have been widely applied in pharmaceuticals and chemicals as a bactericide. Because of the small amount and similar chemical environment of proton, 1H nuclear magnetic resonance(NMR) peaks overlapping of benzimidazole derivative is really in common. In addition, carbon atom has a wide range of chemical shift, a high measurement accuracy and stable in property. The overlapped peaks of 1H NMR via 1H NMR, 13C NMR, ROESY, HSQC, HMBC methods were resolved, as well as the more precise total chemical shift assignment.

关 键 词：核磁共振 归属 二维实验 苯并咪唑类化合物 

分 类 号：S132[农业科学—农业基础科学] O657.2[理学—分析化学]