中国健康成年人抗凝血酶III活性参考值的地理分布  

Geographical distribution of reference values of antithrombin III activity in healthy Chinese adults

作　　者：张雷 葛淼 王晶 杨帆 葛磊 王聪霞[3] ZHANG Lei;GE Miao;WANG Jing;YANG Fan;GE Lei;WANG Congxia(Institute of Health Geography, School of Geography and Tourism, Shaanxi normal University, Xi’an 710119, China;Primary Middle School of Xingping City, Xingping, Shaanxi 713100, China;Department of Cardiology, Second Affiliated Hospital, Medical College of Xi’an Jiaotong University, Xi’an 710004, China)

机构地区：[1]陕西师范大学地理科学与旅游学院健康地理研究所,西安710119 [2]陕西省咸阳市兴平市南市初级中学,陕西兴平713100 [3]西安交通大学医学院第二附属医院心内科,西安710004

出　　处：《华中师范大学学报（自然科学版）》2020年第2期250-257,共8页Journal of Central China Normal University：Natural Sciences

基　　金：国家自然科学基金项目(40971060);陕西省自然科学基础研究计划项目(2019JM-408).

摘　　要：为探讨我国不同地区抗凝血酶III活性的参考值,并分析我国健康成年人抗凝血酶III活性参考值的地理分布.将所收集的我国153个单位8818例健康成年人抗凝血酶III活性参考值,首先通过空间自相关确定其与地理因子之间存在相关性,并确定具体的相关性地理因子;其次运用岭回归分析拟合出我国2322个城市健康成年人的抗凝血酶III活性参考值;最后结合地统计分析,探究我国健康成年人抗凝血酶III的活性参考值的地理分布.结果显示我国健康成年人抗凝血酶III活性参考值具体分布呈东北地区、西北地区和西南大部分地区较低;华北地区、华中地区、华东地区和华南地区较高的趋势.由此若已知我国某地区的地理因素数值,可由此结合预测回归方程:=80.80-0.04430X2+0.1714X5-0.004970X6+0.0008900X7-0.06210X8-0.07626X11+18.97X14-1.692X16-0.03670X18+0.01194X19-0.02360X21±8.55计算出该地区健康成年人抗凝血酶III活性的参考值,进而为该地区实测的抗凝血酶III活性值大小提供科学依据.This work is aimed at exploring the reference value of antithrombin III activity in different areas of China,and analyzing the geographical distribution of reference value of antithrombin III activity in healthy adults in China.The reference values of antithrombin III activity in 8,818 healthy adults from 153 units in China were collected.First,the correlation between antithrombin III activity and geographical factors was determined by spatial autocorrelation,and the geographical factors were specified.Secondly,the reference values of antithrombin III activity of healthy adults in 2,322 cities of China were fitted by ridge regression analysis.Finally,combined with statistical analysis,this paper explores the geographical distribution of active reference values of antithrombin III in healthy adults in China.The results showed that the reference values of antithrombin III activity in healthy adults in China were lower in Northeast,Northwest and Southwest China,while higher in North,Central,East and South China.Therefore,if the value of geographical factors in a certain area of China is known,the reference value of antithrombin III activity of healthy adults in this area was able to be calculated in combination with the predicted regression equation:=80.80-0.04430X2+0.1714X5-0.004970X6+0.0008900X7-0.06210X8-0.07626X11+18.97X14-1.692X16-0.03670X18+0.01194X19-0.02360X21±8.55,providing a theoretical reference for the measured value in the corresponding region.

关 键 词：抗凝血酶III活性 空间自相关 岭回归 克里金插值 地理分布 

分 类 号：R188[医药卫生—流行病学]