试用材料学理论解心肌复原和心肌缓解关联之惑  

Trial hypothesis of materials science to solve puzzle of myocardial recovery and remission association

作　　者：李海嵘[1] 陈关良[1] 方小丽[1] 蔡兴赳[1] 许荣丽[1] 林慕如[1] LI Hairong;CHEN Guanliang;FANG Xiaoli;CAI Xingjiu;XU Rongli;LIN Muru(Department of Cardiology,Hainan Provincial People’s Hospital,Institution of Cardiology,Hainan Clinical Medical College,Haikou 570311,China)

机构地区：[1]海南省人民医院心血管内科,海南省临床医学研究院心血管病研究所,海南海口570311

出　　处：《医学争鸣》2020年第2期39-41,共3页Negative

基　　金：国家临床重点专科建设项目(卫办医政函〔2011〕873号)。

摘　　要：逆重构的发现给传统以纠正神经—体液异常激活为主的心力衰竭治疗策略提供了全新的思路,有望改善目前心力衰竭治疗现状。但逆重构中心肌复原和心肌缓解之间的关联给研究者带来巨大的困惑。并且,现有通过患者预后结局回顾性判断心肌复原和心肌缓解的办法严重滞后于临床治疗,不利于在疾病早期开展前瞻性研究。为此,笔者尝试从一个新的角度出发,借鉴材料学相关理论,提出“重构限度”假说论述二者关联,希望开拓思路,解决目前临床遇到的困惑。The discovery of reverse remodeling provides a new way of thinking about the traditional heart failure treatment strategy to correct neuro-humoral abnormal activation,and it is expected to improve the current treatment status of heart failure.However,the association between myocardial recovery and myocardial remission in reverse remodeling has brought great confusion to researchers.Moreover,the current method of retrospectively judging myocardial recovery and myocardial remission through the prognosis of patients is seriously lagging behind clinical treatment,which is not conducive to prospective studies on the early stage of the disease.To this end,the author attempts to start from a new perspective,draws on the relevant theories of hylology,and puts forward the“remodeling limit”hypothesis to discuss the relationship between the two,and hopes to open up ideas and solve the current clinical confusion.

关 键 词：逆重构 材料学 心肌复原 心肌缓解 

分 类 号：R54[医药卫生—心血管疾病]