献血者血液筛查中ALT与HBV、HCV的相关性分析  

Correlation Analysis of ALT and HBV,HCV in Blood Screening of Blood Donors

作　　者：王瑞仙 WANG Rui-xian(Qujing Blood Center,Qujing 655000,China)

机构地区：[1]曲靖市中心血站,云南曲靖655000

出　　处：《中国医药指南》2020年第11期54-55,共2页Guide of China Medicine

摘　　要：目的对曲靖地区献血者中丙氨酸氨基转移酶(ALT)与乙型肝炎表面抗原(HBsAg)、HBV-DNA、丙型肝炎抗体(HCV-Ab)、HCV-RNA的相关性分析,为招募低风险的献血者提供依据,提高血液安全。方法对本地区2015年~2017年116414份献血者血液进行ALT、HBsAg、HBV-DNA、HCV-Ab、HCV-RNA检测,并对ALT、HBsAg、HBV-DNA、HCV-Ab、HCV-RNA的结果进行相关性分析。结果2015年1月至2017年12月在本站共116414人份无偿献血者的标本进行检测,ALT异常者3660人份,不合格率为3.14%;HBsAg阳性452份,不合格率为0.39%;HCV-Ab阳性279份,不合格率为0.24%;HBV-DNA阳性94份,不合格率为0.081%。HBsAg和HBVDNA阳性者中ALT的异常率和HBsAg和HBV-DNA阴性者中ALT的异常率无统计学差异(P>0.05)HCV-Ab阳性者中ALT的异常率与HCV-Ab阴性者中ALT的异常率有统计学差异(P<0.01)。结论单项ALT的升高和乙型肝炎病毒的感染没有相关性,单项ALT的升高和丙型肝炎病毒的感染有一定相关性。虽然ALT的升高和丙型肝炎病毒的感染有相关性,但仅占ALT阳性的比率为0.49%(18/3660),所占比率很有限,所以本人认为从保护血液资源的角度考虑还是应该调整ALT的阈值或者取消ALT在献血者标本中的检测。Objective The correlation between alanine aminotransferase(ALT)and hepatitis B surface antigen(HBsAg),HBV-DNA,)hepatitis C antibody(HCV-Ab)and HCV-RNA in blood donors in Qujing area was analyzed in order to provide basis for recruiting low risk blood donors and improve blood safety.Methods ALT,HBsAg,HBV-DNA,HCV-Ab,HCV-RNA was performed on 116414 blood donors from 2015 to 2017,and the results of ALT,HBsAg,HBV-DNA,HCV-Ab,HCVRNA were compared.Relevance analysis Results From January 2015 to December 2017,3660 samples of ALT were abnormal and 452 samples were positive for HBsAg,and the unqualifi ed rate was 0.39%.The positive rate of HCV-Ab was 279,the unqualifi ed rate was 0.24%HBV-DNA was positive in 94 cases.The abnormal rate of ALT in 0.081%.HBsAg and HBV-DNA positive patients was not signifi cantly different from that of ALT in HBsAg and HBV-DNA negative patients(P<0.05).The abnormal rate of ALT in HCV-Ab positive group was signifi cantly higher than that in HCV-Ab negative group(P<0.01).Conclusion There is no correlation between the increase of single ALT and the infection of hepatitis B virus,but there is a certain correlation between the increase of single ALT and the infection of hepatitis C virus.Although the increase in ALT is associated with hepatitis C virus infection,it is only 0.49%(18/3660)of ALT positive,which is very limited.So I think we should adjust the threshold of ALT or cancel the detection of ALT in blood donors from the point of view of protecting blood resources.

关 键 词：ALT HBsAg HBV-DNA HCV-AB HCV-RNA 

分 类 号：R512.6[医药卫生—内科学]